Crystal structure of a ternary ligand-receptor complex of BMP-2

Summary for 2H64

Related1REU 2H62
DescriptorBone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Acvr2b protein, ... (4 entities in total)
Functional Keywordstgf-beta superfamily, ligand-receptor complex, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P12643
Membrane; Single-pass type I membrane protein P36894
Total number of polymer chains3
Total molecular weight38789.55
Mueller, T.D.,Sebald, W.,Weber, D. (deposition date: 2006-05-30, release date: 2007-04-10, Last modification date: 2011-07-13)
Primary citation
Weber, D.,Kotzsch, A.,Nickel, J.,Harth, S.,Seher, A.,Mueller, U.,Sebald, W.,Mueller, T.D.
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7:6-6, 2007
PubMed: 17295905 (PDB entries with the same primary citation)
DOI: 10.1186/1472-6807-7-6
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26413 0.7% 2.7% 6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02