2H64
Crystal structure of a ternary ligand-receptor complex of BMP-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bone morphogenetic protein 2 | polymer | 114 | 12940.9 | 1 | UniProt (P12643) Pfam (PF00019) | Homo sapiens (human) | BMP-2, BMP-2A |
| 2 | B (B) | Bone morphogenetic protein receptor type IA | polymer | 129 | 14199.9 | 1 | UniProt (P36894) Pfam (PF01064) | Homo sapiens (human) | Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen |
| 3 | C (C) | Acvr2b protein | polymer | 99 | 11648.8 | 1 | UniProt (Q3KQI1) Pfam (PF01064) UniProt (by SIFTS) (P27040) | Mus musculus (house mouse) | Activin receptor type IIB |
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 114 (UniProt: P12643)
| PDB | External Database | Details |
|---|---|---|
| Lys 100 | Leu 382 | engineered mutation |
| Asp 102 | Asn 384 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 38789.6 | |
| All* | Total formula weight | 38789.6 |
