4UI0

Crystal structure of the human RGMB-BMP2 complex, crystal form 2

Summary for 4UI0

Entry DOI	10.2210/pdb4ui0/pdb
Related	4UHY 4UHZ 4UI1 4UI2
Descriptor	BONE MORPHOGENETIC PROTEIN 2, RGM DOMAIN FAMILY MEMBER B, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	signaling protein, repulsive guidance molecule, bone morphogenetic protein pathway, hemojuvelin, morphogen, axon guidance, cell surface receptor signaling
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: P12643 Cell membrane ; Lipid-anchor, GPI-anchor : Q6NW40
Total number of polymer chains	3
Total formula weight	36723.14
Authors	Healey, E.G.,Bishop, B.,Elegheert, J.,Bell, C.H.,Padilla-Parra, S.,Siebold, C. (deposition date: 2015-03-27, release date: 2015-05-06, Last modification date: 2015-06-17)
Primary citation	Healey, E.G.,Bishop, B.,Elegheert, J.,Bell, C.H.,Padilla-Parra, S.,Siebold, C. Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22:458-, 2015 Cited by PubMed: 25938661 DOI: 10.1038/NSMB.3016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation