5BV8
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![BU of 5bv8 by Molmil](/molmil-images/mine/5bv8) | G1324S mutation in von Willebrand Factor A1 domain | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, von Willebrand factor | Authors: | Campbell, J.C, Kim, C, Tischer, A, Auton, M. | Deposit date: | 2015-06-04 | Release date: | 2015-12-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor. J.Biol.Chem., 291, 2016
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7EOW
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![BU of 7eow by Molmil](/molmil-images/mine/7eow) | |
3ZQK
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![BU of 3zqk by Molmil](/molmil-images/mine/3zqk) | Von Willebrand Factor A2 domain with calcium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Jakobi, A.J, Huizinga, E.G. | Deposit date: | 2011-06-09 | Release date: | 2011-07-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Calcium Modulates Force Sensing by the Von Willebrand Factor A2 Domain. Nat.Commun., 2, 2011
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1IJB
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![BU of 1ijb by Molmil](/molmil-images/mine/1ijb) | The von Willebrand Factor mutant (I546V) A1 domain | Descriptor: | von Willebrand factor | Authors: | Fukuda, K, Doggett, T.A, Bankston, L.A, Cruz, M.A, Diacovo, T.G, Liddington, R.C. | Deposit date: | 2001-04-25 | Release date: | 2002-07-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure, 10, 2002
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1ATZ
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![BU of 1atz by Molmil](/molmil-images/mine/1atz) | HUMAN VON WILLEBRAND FACTOR A3 DOMAIN | Descriptor: | VON WILLEBRAND FACTOR | Authors: | Huizinga, E.G, Gros, P. | Deposit date: | 1997-08-15 | Release date: | 1998-02-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Structure, 5, 1997
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3GXB
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![BU of 3gxb by Molmil](/molmil-images/mine/3gxb) | Crystal structure of VWF A2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | Authors: | Zhou, Y.F, Springer, T.A. | Deposit date: | 2009-04-02 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc.Natl.Acad.Sci.USA, 106, 2009
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3PPW
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![BU of 3ppw by Molmil](/molmil-images/mine/3ppw) | Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3PPV
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![BU of 3ppv by Molmil](/molmil-images/mine/3ppv) | Crystal structure of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | CALCIUM ION, SULFATE ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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2ADF
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![BU of 2adf by Molmil](/molmil-images/mine/2adf) | Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain | Descriptor: | 82D6A3 IgG, ACETIC ACID, GLYCEROL, ... | Authors: | Staelens, S, Hadders, M.A, Vauterin, S, Platteau, C, Vanhoorelbeke, K, Huizinga, E.G, Deckmyn, H. | Deposit date: | 2005-07-20 | Release date: | 2005-12-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain J.Biol.Chem., 281, 2006
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3PPX
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![BU of 3ppx by Molmil](/molmil-images/mine/3ppx) | Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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3PPY
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![BU of 3ppy by Molmil](/molmil-images/mine/3ppy) | Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) | Descriptor: | SODIUM ION, von Willebrand factor | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | Deposit date: | 2010-11-25 | Release date: | 2011-05-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood, 117, 2011
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1FNS
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1FE8
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![BU of 1fe8 by Molmil](/molmil-images/mine/1fe8) | CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, IMMUNOGLOBULIN IGG RU5, ... | Authors: | Bouma, B, Huizinga, E.G, Schiphorst, M.E, Sixma, J.J, Kroon, J, Gros, P. | Deposit date: | 2000-07-21 | Release date: | 2001-04-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Identification of the collagen-binding site of the von Willebrand factor A3-domain. J.Biol.Chem., 276, 2001
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4C2A
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![BU of 4c2a by Molmil](/molmil-images/mine/4c2a) | Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha | Descriptor: | ACETATE ION, CACODYLATE ION, CALCIUM ION, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.081 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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7F49
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![BU of 7f49 by Molmil](/molmil-images/mine/7f49) | von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA | Descriptor: | BT-100, GLYCEROL, von Willebrand factor | Authors: | Zhu, S. | Deposit date: | 2021-06-18 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer J Thromb Haemost., 18, 2020
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1AO3
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![BU of 1ao3 by Molmil](/molmil-images/mine/1ao3) | |
1OAK
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4C29
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![BU of 4c29 by Molmil](/molmil-images/mine/4c29) | Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation | Descriptor: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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1AUQ
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![BU of 1auq by Molmil](/molmil-images/mine/1auq) | A1 DOMAIN OF VON WILLEBRAND FACTOR | Descriptor: | A1 DOMAIN OF VON WILLEBRAND FACTOR, CADMIUM ION | Authors: | Emsley, J, Cruz, M, Handin, R, Liddington, R. | Deposit date: | 1997-09-01 | Release date: | 1998-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib. J.Biol.Chem., 273, 1998
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3HXO
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![BU of 3hxo by Molmil](/molmil-images/mine/3hxo) | Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding | Descriptor: | Aptamer ARC1172, von Willebrand factor | Authors: | Huang, R.H, Sadler, J.E, Fremont, D.H, Diener, J.L, Schaub, R.G. | Deposit date: | 2009-06-21 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure, 17, 2009
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6N29
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![BU of 6n29 by Molmil](/molmil-images/mine/6n29) | Crystal structure of monomeric von Willebrand Factor D`D3 assembly | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Dong, X, Arndt, J.W, Springer, T.A. | Deposit date: | 2018-11-12 | Release date: | 2019-01-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. Blood, 133, 2019
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1IJK
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![BU of 1ijk by Molmil](/molmil-images/mine/1ijk) | The von Willebrand Factor mutant (I546V) A1 domain-botrocetin Complex | Descriptor: | Botrocetin, von Willebrand factor | Authors: | Fukuda, K, Doggett, T.A, Bankston, L.A, Cruz, M.A, Diacovo, T.G, Liddington, R.C. | Deposit date: | 2001-04-26 | Release date: | 2002-07-10 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure, 10, 2002
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1SQ0
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![BU of 1sq0 by Molmil](/molmil-images/mine/1sq0) | Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution | Descriptor: | Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin], Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II] | Authors: | Dumas, J.J, Kumar, R, McDonagh, T, Sullivan, F, Stahl, M.L, Somers, W.S, Mosyak, L. | Deposit date: | 2004-03-17 | Release date: | 2004-04-13 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations J.Biol.Chem., 279, 2004
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3HXQ
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![BU of 3hxq by Molmil](/molmil-images/mine/3hxq) | Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding | Descriptor: | Aptamer ARC1172, von Willebrand Factor | Authors: | Huang, R.H, Sadler, J.E, Fremont, D.H, Diener, J.L, Schaub, R.G. | Deposit date: | 2009-06-21 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.694 Å) | Cite: | A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure, 17, 2009
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4C2B
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![BU of 4c2b by Molmil](/molmil-images/mine/4c2b) | Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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