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3HXO

Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding

Summary for 3HXO
Entry DOI10.2210/pdb3hxo/pdb
Related3HXQ
Descriptorvon Willebrand factor, Aptamer ARC1172 (3 entities in total)
Functional Keywordsarc1779, vwf, platelet glycoprotein ib, aptamer, arc1772, blood coagulation, cell adhesion, cleavage on pair of basic residues, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hemostasis, isopeptide bond, secreted, von willebrand disease, blood clotting-blood clotting regulator complex, blood clotting/blood clotting regulator
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight36773.82
Authors
Huang, R.H.,Sadler, J.E.,Fremont, D.H.,Diener, J.L.,Schaub, R.G. (deposition date: 2009-06-21, release date: 2009-11-17, Last modification date: 2023-09-06)
Primary citationHuang, R.H.,Fremont, D.H.,Diener, J.L.,Schaub, R.G.,Sadler, J.E.
A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.
Structure, 17:1476-1484, 2009
Cited by
PubMed: 19913482
DOI: 10.1016/j.str.2009.09.011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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