3HXO
Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
Summary for 3HXO
Entry DOI | 10.2210/pdb3hxo/pdb |
Related | 3HXQ |
Descriptor | von Willebrand factor, Aptamer ARC1172 (3 entities in total) |
Functional Keywords | arc1779, vwf, platelet glycoprotein ib, aptamer, arc1772, blood coagulation, cell adhesion, cleavage on pair of basic residues, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hemostasis, isopeptide bond, secreted, von willebrand disease, blood clotting-blood clotting regulator complex, blood clotting/blood clotting regulator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 36773.82 |
Authors | Huang, R.H.,Sadler, J.E.,Fremont, D.H.,Diener, J.L.,Schaub, R.G. (deposition date: 2009-06-21, release date: 2009-11-17, Last modification date: 2023-09-06) |
Primary citation | Huang, R.H.,Fremont, D.H.,Diener, J.L.,Schaub, R.G.,Sadler, J.E. A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure, 17:1476-1484, 2009 Cited by PubMed: 19913482DOI: 10.1016/j.str.2009.09.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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