1FNS

CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR (VWF) A1 DOMAIN I546V MUTANT IN COMPLEX WITH THE FUNCTION BLOCKING FAB NMC4

Summary for 1FNS

Entry DOI	10.2210/pdb1fns/pdb
Descriptor	IMMUNOGLOBULIN NMC-4 IGG1, VON WILLEBRAND FACTOR, ... (4 entities in total)
Functional Keywords	von willebrand factor, glycoprotein iba (a:alpha) binding, complex (willebrand-immunoglobulin), blood coagulation type 2b von willebrand disease, immune system
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P04275
Total number of polymer chains	3
Total formula weight	70230.02
Authors	Varughese, K.I. (deposition date: 2000-08-23, release date: 2000-10-18, Last modification date: 2011-11-16)
Primary citation	Celikel, R.,Ruggeri, Z.M.,Varughese, K.I. von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule. Nat.Struct.Biol., 7:881-884, 2000 Cited by PubMed: 11017197 DOI: 10.1038/79639 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation