7EOW

High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine

Summary for 7EOW

• Entry DOI: 10.2210/pdb7eow/pdb
• Descriptor: von Willebrand factor, caplacizumab (3 entities in total)
• Functional Keywords: vwf, vfw a1, caplacizumab, nanobody, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 41567.22

Authors

Lee, H.T.,Heo, Y.-S. (deposition date: 2021-04-23, release date: 2021-07-07, Last modification date: 2023-11-29)

• Primary citation: Lee, H.T.,Park, U.B.,Jeong, T.J.,Gu, N.,Lee, S.H.,Kim, Y.,Heo, Y.S.; High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP.; Biochem.Biophys.Res.Commun., 567:49-55, 2021; PubMed: 34144500; DOI: 10.1016/j.bbrc.2021.06.030

Experimental method

X-RAY DIFFRACTION (1.6 Å)