7EOW

High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	von Willebrand factor	polymer	232	26508.4	1	UniProt (P04275) Pfam (PF00092)	Homo sapiens (Human)	vWF
2	B (B)	caplacizumab	polymer	137	15058.8	1		Homo sapiens (Human)
3	C, D (A, B)	water	water		18.0	380	Chemie (HOH)

Sequence modifications

A: 25 - 232 (UniProt: P04275)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Glu 14	-	expression tag
Asn 15	-	expression tag
Leu 16	-	expression tag
Tyr 17	-	expression tag
Phe 18	-	expression tag
Gln 19	-	expression tag
Ser 20	-	expression tag
Gly 21	-	expression tag
Ser 22	-	expression tag
His 23	-	expression tag
Met 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	41567.2
All*	Total formula weight	41567.2

*Water molecules are not included.