7F49

von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA

Summary for 7F49

• Entry DOI: 10.2210/pdb7f49/pdb
• Descriptor: von Willebrand factor, BT-100, GLYCEROL, ... (4 entities in total)
• Functional Keywords: aptamers, arterial thrombosis, platelets, primates, von willebrand factor, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34121.49

Authors

Zhu, S. (deposition date: 2021-06-18, release date: 2021-07-07, Last modification date: 2024-11-06)

Primary citation

Zhu, S.,Gilbert, C.J.
The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer
J Thromb Haemost., 18:1113-1123, 2020

PubMed Abstract: Thrombus formation involves coagulation proteins and platelets. The latter, referred to as platelet-mediated thrombogenesis, is predominant in arterial circulation. Platelet thrombogenesis follows vascular injury when extracellular von Willebrand factor (VWF) binds via its A3 domain to exposed collagen, and the free VWF A1 domain binds to platelet glycoprotein Ib (GPIb).

PubMed: 32011054
DOI: 10.1111/jth.14755

Experimental method

X-RAY DIFFRACTION (2.09 Å)