1SQ0

Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution

Summary for 1SQ0

Entry DOI	10.2210/pdb1sq0/pdb
Related	1AUQ 1M0Z 1M10 1OOK 1P8V
Descriptor	Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II], Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin] (3 entities in total)
Functional Keywords	leucine rich repeat (lrr), right-handed beta-alpha superhelix); integrin a (or i) domain fold, blood clotting
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P04275 Membrane; Single-pass type I membrane protein: P07359
Total number of polymer chains	2
Total formula weight	56550.86
Authors	Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L. (deposition date: 2004-03-17, release date: 2004-04-13, Last modification date: 2021-10-27)
Primary citation	Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L. Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations J.Biol.Chem., 279:23327-23334, 2004 Cited by PubMed: 15039442 DOI: 10.1074/jbc.M401659200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation