1SQ0

Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution

Summary for 1SQ0

Related1M10 1M0Z 1AUQ 1P8V 1OOK
DescriptorVon Willebrand factor (vWF) [Contains: Von Willebrand antigen II], Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin] (3 entities in total)
Functional Keywordsleucine rich repeat (lrr), right-handed beta-alpha superhelix); integrin a (or i) domain fold, blood clotting
Biological sourceHomo sapiens (human)
Cellular locationSecreted P04275
Membrane; Single-pass type I membrane protein P07359
Total number of polymer chains2
Total molecular weight56550.86
Authors
Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L. (deposition date: 2004-03-17, release date: 2004-04-13, Last modification date: 2011-07-13)
Primary citation
Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L.
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations
J.Biol.Chem., 279:23327-23334, 2004
PubMed: 15039442 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M401659200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.241190.7%6.3%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1sq0
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Molmil generated image of 1sq0
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Molmil generated image of 1sq0
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