7BAH
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![BU of 7bah by Molmil](/molmil-images/mine/7bah) | Structure of RIG-I CTD bound to OH-RNA | Descriptor: | Antiviral innate immune response receptor RIG-I, RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3'), ZINC ION | Authors: | Anand, K, Hagelueken, G, Fusshoeller, D, Geyer, M. | Deposit date: | 2020-12-15 | Release date: | 2022-01-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A conserved isoleucine in the RNA sensor RIG-I controls immune tolerance to mitochondrial RNA To Be Published
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7MK1
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![BU of 7mk1 by Molmil](/molmil-images/mine/7mk1) | Structure of a protein-modified aptamer complex | Descriptor: | Antiviral innate immune response receptor RIG-I, DNA (41-MER), MAGNESIUM ION, ... | Authors: | Ren, X, Pyle, A.M. | Deposit date: | 2021-04-21 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA. J.Mol.Biol., 433, 2021
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3LRR
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![BU of 3lrr by Molmil](/molmil-images/mine/3lrr) | Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3'), ZINC ION | Authors: | Li, P. | Deposit date: | 2010-02-11 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain. Structure, 18, 2010
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3OG8
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![BU of 3og8 by Molmil](/molmil-images/mine/3og8) | Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION | Authors: | Li, P. | Deposit date: | 2010-08-16 | Release date: | 2010-11-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate. Nucleic Acids Res., 39, 2011
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3ZD7
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![BU of 3zd7 by Molmil](/molmil-images/mine/3zd7) | Snapshot 3 of RIG-I scanning on RNA duplex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, ... | Authors: | Luo, D, Pyle, A.M. | Deposit date: | 2012-11-25 | Release date: | 2013-08-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Defining the Functional Determinants for RNA Surveillance by Rig-I. Embo Rep., 14, 2013
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2YKG
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![BU of 2ykg by Molmil](/molmil-images/mine/2ykg) | Structural insights into RNA recognition by RIG-I | Descriptor: | 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3', PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, SULFATE ION, ... | Authors: | Luo, D, Pyle, A.M. | Deposit date: | 2011-05-27 | Release date: | 2011-10-26 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Insights Into RNA Recognition by Rig-I. Cell(Cambridge,Mass.), 147, 2011
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3NCU
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![BU of 3ncu by Molmil](/molmil-images/mine/3ncu) | |
4BPB
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![BU of 4bpb by Molmil](/molmil-images/mine/4bpb) | STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I | Descriptor: | 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3', PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, SULFATE ION, ... | Authors: | Luo, D, Pyle, A.M. | Deposit date: | 2013-05-23 | Release date: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.584 Å) | Cite: | Structural Insights Into RNA Recognition by Rig-I. Cell(Cambridge,Mass.), 147, 2011
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3LRN
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![BU of 3lrn by Molmil](/molmil-images/mine/3lrn) | Crystal structure of human RIG-I CTD bound to a 14 bp GC 5' ppp dsRNA | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION | Authors: | Li, P. | Deposit date: | 2010-02-11 | Release date: | 2010-06-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain. Structure, 18, 2010
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5F9F
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![BU of 5f9f by Molmil](/molmil-images/mine/5f9f) | Crystal structure of RIG-I helicase-RD in complex with 24-mer blunt-end hairpin RNA | Descriptor: | (R,R)-2,3-BUTANEDIOL, MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, ... | Authors: | Wang, C, Marcotrigiano, J, Miller, M.T, Jiang, F. | Deposit date: | 2015-12-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proc.Natl.Acad.Sci.USA, 113, 2016
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2QFD
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![BU of 2qfd by Molmil](/molmil-images/mine/2qfd) | Crystal structure of the regulatory domain of human RIG-I with bound Hg | Descriptor: | MERCURY (II) ION, Probable ATP-dependent RNA helicase DDX58 | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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5E3H
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![BU of 5e3h by Molmil](/molmil-images/mine/5e3h) | Structural Basis for RNA Recognition and Activation of RIG-I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, GLYCEROL, ... | Authors: | Jiang, F, Miller, M.T, Marcotrigiano, J. | Deposit date: | 2015-10-02 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature, 479, 2011
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4ON9
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![BU of 4on9 by Molmil](/molmil-images/mine/4on9) | DECH box helicase domain | Descriptor: | CHLORIDE ION, Probable ATP-dependent RNA helicase DDX58, SULFATE ION | Authors: | Deimling, T, Witte, G, Hopfner, K.P. | Deposit date: | 2014-01-28 | Release date: | 2014-07-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal and solution structure of the human RIG-I SF2 domain Acta Crystallogr.,Sect.F, 70, 2014
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3ZD6
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![BU of 3zd6 by Molmil](/molmil-images/mine/3zd6) | Snapshot 1 of RIG-I scanning on RNA duplex | Descriptor: | PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, RNA DUPLEX, ZINC ION | Authors: | Luo, D, Pyle, A.M. | Deposit date: | 2012-11-25 | Release date: | 2013-08-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Defining the Functional Determinants for RNA Surveillance by Rig-I. Embo Rep., 14, 2013
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4AY2
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![BU of 4ay2 by Molmil](/molmil-images/mine/4ay2) | Capturing 5' tri-phosphorylated RNA duplex by RIG-I | Descriptor: | 5'-R-PPP(GP*GP*CP*GP*CP*GP*GP*CP*UP*UP*CP*GP*GP*CP *CP*GP*CP*GP*CP*C)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Luo, D, Pyle, A.M. | Deposit date: | 2012-06-17 | Release date: | 2012-10-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor Rig-I. Structure, 20, 2012
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6GPG
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![BU of 6gpg by Molmil](/molmil-images/mine/6gpg) | Structure of the RIG-I Singleton-Merten syndrome variant C268F | Descriptor: | MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3'), ... | Authors: | Laessig, C, Lammens, K, Hopfner, K.-P. | Deposit date: | 2018-06-05 | Release date: | 2018-08-08 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.894 Å) | Cite: | Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants. Elife, 7, 2018
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8DVU
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![BU of 8dvu by Molmil](/molmil-images/mine/8dvu) | |
8DVS
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![BU of 8dvs by Molmil](/molmil-images/mine/8dvs) | Cryo-EM structure of RIG-I bound to the end of OHSLR30 (+ATP) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, MAGNESIUM ION, ... | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-07-29 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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6KYV
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![BU of 6kyv by Molmil](/molmil-images/mine/6kyv) | Crystal Structure of RIG-I and hairpin RNA with G-U wobble base pairs | Descriptor: | Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*GP*GP*UP*AP*GP*AP*CP*GP*CP*UP*UP*CP*GP*GP*CP*GP*UP*UP*UP*GP*CP*C)-3'), ZINC ION | Authors: | Kim, K.-H, Hwang, J, Kim, J.H, Son, K.-P, Jang, Y, Kim, M, Kang, S.-J, Lee, J.-O, Choi, B.-S. | Deposit date: | 2019-09-20 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs. Rna Biol., 17, 2020
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2QFB
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![BU of 2qfb by Molmil](/molmil-images/mine/2qfb) | Crystal structure of the regulatory domain of human RIG-I with bound Zn | Descriptor: | Probable ATP-dependent RNA helicase DDX58, ZINC ION | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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5F9H
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![BU of 5f9h by Molmil](/molmil-images/mine/5f9h) | Crystal structure of RIG-I helicase-RD in complex with 24-mer 5' triphosphate hairpin RNA | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, ... | Authors: | Wang, C, Marcotrigiano, J, Miller, M, Jiang, F. | Deposit date: | 2015-12-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proc.Natl.Acad.Sci.USA, 113, 2016
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8G7T
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![BU of 8g7t by Molmil](/molmil-images/mine/8g7t) | Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end) | Descriptor: | Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ZINC ION, ... | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2023-02-17 | Release date: | 2023-11-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Nat Commun, 14, 2023
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7TNY
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![BU of 7tny by Molmil](/molmil-images/mine/7tny) | Cryo-EM structure of RIG-I in complex with p2dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, ZINC ION, p2dsRNA | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TO2
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![BU of 7to2 by Molmil](/molmil-images/mine/7to2) | |
5F98
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![BU of 5f98 by Molmil](/molmil-images/mine/5f98) | Crystal structure of RIG-I in complex with Cap-0 RNA | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, ... | Authors: | Wang, C, Marcotrigiano, J, Miller, M, Jiang, F. | Deposit date: | 2015-12-09 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proc.Natl.Acad.Sci.USA, 113, 2016
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