3QEK
 
 | | Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NMDA glutamate receptor subunit, POTASSIUM ION, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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6E7R
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6E7U
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6E7T
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6E7X
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6E7V
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3QEL
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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6E7W
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5TQ0
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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6E7S
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5EWM
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5EWJ
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8G18
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5B3J
 | | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | | Descriptor: | Fab, heavy chain, light chain, ... | | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | Deposit date: | 2016-03-01 | | Release date: | 2016-05-11 | | Last modified: | 2022-03-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 534, 2016
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5TPW
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.909 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5EWL
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3QEM
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.003 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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5TPZ
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ... | | Authors: | Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.095 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TQ2
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.289 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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4TLL
 | | Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 | | Descriptor: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | | Authors: | Gouaux, E, Lee, C.-H, Lu, W. | | Deposit date: | 2014-05-30 | | Release date: | 2014-07-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.59 Å) | | Cite: | NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
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5UN1
 | | Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor | | Descriptor: | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Song, X, Gouaux, E. | | Deposit date: | 2017-01-30 | | Release date: | 2018-02-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Mechanism of NMDA receptor channel block by MK-801 and memantine.
Nature, 556, 2018
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4TLM
 | | Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 | | Descriptor: | 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... | | Authors: | Gouaux, E, Lee, C.-H, Lu, W. | | Deposit date: | 2014-05-30 | | Release date: | 2014-07-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.77 Å) | | Cite: | NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
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5UOW
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | Descriptor: | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Lu, W, Du, J, Goehring, A, Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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7TE6
 | | Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody | | Descriptor: | Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ... | | Authors: | Regan, M, Tajima, N, Furukawa, H. | | Deposit date: | 2022-01-04 | | Release date: | 2022-03-02 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.55 Å) | | Cite: | Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
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5UP2
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GluN2B-specific Fab, ... | | Authors: | Lu, W, Du, J, Goehring, A, Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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