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5EWM

CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH EVT-101

Summary for 5EWM
Entry DOI10.2210/pdb5ewm/pdb
Related5WMJ 5WML
DescriptorNMDA glutamate receptor subunit, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsglutamate receptor, allosteric modulator, glun2b antagonists, transport protein
Biological sourceXenopus laevis (African clawed frog)
More
Total number of polymer chains4
Total formula weight173209.37
Authors
Pandit, J. (deposition date: 2015-11-20, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citationStroebel, D.,Buhl, D.L.,Knafels, J.D.,Chanda, P.K.,Green, M.,Sciabola, S.,Mony, L.,Paoletti, P.,Pandit, J.
A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
Mol.Pharmacol., 89:541-551, 2016
Cited by
PubMed: 26912815
DOI: 10.1124/mol.115.103036
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.76 Å)
Structure validation

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