5EWJ

CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH IFENPRODIL

Summary for 5EWJ

Entry DOI	10.2210/pdb5ewj/pdb
Related	5EWL 5EWM
Descriptor	NMDA glutamate receptor subunit, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	glutamate receptor, allosteric modulator, glun2b antagonists, transport protein
Biological source	Xenopus laevis (African clawed frog) More
Total number of polymer chains	4
Total formula weight	173154.70
Authors	Pandit, J. (deposition date: 2015-11-20, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Stroebel, D.,Buhl, D.L.,Knafels, J.D.,Chanda, P.K.,Green, M.,Sciabola, S.,Mony, L.,Paoletti, P.,Pandit, J. A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists. Mol.Pharmacol., 89:541-551, 2016 Cited by PubMed: 26912815 DOI: 10.1124/mol.115.103036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.77 Å)

Structure validation