5EWJ
CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH IFENPRODIL
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | NMDA glutamate receptor subunit | polymer | 390 | 43758.0 | 2 | UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) In PDB | Xenopus laevis (African clawed frog) | |
2 | B, D | Glutamate receptor ionotropic, NMDA 2B | polymer | 364 | 41351.9 | 2 | UniProt (Q13224) Pfam (PF01094) In PDB | Homo sapiens (Human) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3 |
3 | E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
4 | A, C | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
6 | B, D | 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol | non-polymer | 325.4 | 2 | Chemie (QEL) | |||
7 | water | water | 18.0 | 351 | Chemie (HOH) |
Sequence modifications
A, C: 23 - 408 (UniProt: Q91977)
B, D: 31 - 394 (UniProt: Q13224)
PDB | External Database | Details |
---|---|---|
Gln 61 | Asn 61 | engineered mutation |
Gln 371 | Asn 371 | engineered mutation |
Leu 409 | - | expression tag |
Val 410 | - | expression tag |
Pro 411 | - | expression tag |
Arg 412 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 348 | Asn 348 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 170219.8 | |
Branched | Number of molecules | 1 |
Total formula weight | 910.8 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2024.1 | |
All* | Total formula weight | 173154.7 |