5EWJ

CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH IFENPRODIL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	NMDA glutamate receptor subunit	polymer	390	43758.0	2	UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9)	Xenopus laevis (African clawed frog)
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 2B	polymer	364	41351.9	2	UniProt (Q13224) Pfam (PF01094)	Homo sapiens (Human)	GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3
3	E (E)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	F, K (A, C)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	G, H, I, L, M... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	J, O (B, D)	4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol	non-polymer		325.4	2	Chemie (QEL)
7	P, Q, R, S (A, B, C, D)	water	water		18.0	351	Chemie (HOH)

Sequence modifications

A, C: 23 - 408 (UniProt: Q91977)

PDB	External Database	Details
Gln 61	Asn 61	engineered mutation
Gln 371	Asn 371	engineered mutation
Leu 409	-	expression tag
Val 410	-	expression tag
Pro 411	-	expression tag
Arg 412	-	expression tag

B, D: 31 - 394 (UniProt: Q13224)

PDB	External Database	Details
Asp 348	Asn 348	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170219.8
Branched	Number of molecules	1
	Total formula weight	910.8
Non-Polymers*	Number of molecules	10
	Total formula weight	2024.1
All*	Total formula weight	173154.7

*Water molecules are not included.