4NWU
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6DC4
| RSV-neutralizing human antibody AM22 | Descriptor: | 1,2-ETHANEDIOL, Fab AM22 Heavy Chain, Fab AM22 Light Chain | Authors: | Jones, H.G, McLellan, J.S. | Deposit date: | 2018-05-04 | Release date: | 2019-07-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Alternative conformations of a major antigenic site on RSV F. Plos Pathog., 15, 2019
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6ARP
| Structure of a mutant Cetuximab Fab fragment | Descriptor: | Cetuximab mutant Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Cetuximab mutant light chain,Uncharacterized protein, GLYCEROL, ... | Authors: | Christie, M, Christ, D. | Deposit date: | 2017-08-23 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of a mutant Cetuximab Fab fragment To Be Published
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6UC5
| Fab397 in complex with NPNA peptide | Descriptor: | Fab397 heavy chain, Fab397 light chain, NPNA peptide | Authors: | Pholcharee, T, Oyen, D, Wilson, I.A. | Deposit date: | 2019-09-13 | Release date: | 2020-01-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein. J.Mol.Biol., 432, 2020
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4NWT
| Crystal structure of the anti-human NGF Fab APE1531 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, APE1531 Ab Fab heavy chain, ... | Authors: | Verdino, P, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2013-12-06 | Release date: | 2014-10-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. J.Biol.Chem., 289, 2014
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3MNZ
| Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide bearing Ala substitutions in a helical conformation | Descriptor: | ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, SODIUM ION, ... | Authors: | Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. | Deposit date: | 2010-04-22 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
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1N0X
| Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, B2.1 peptide, GLYCEROL, ... | Authors: | Saphire, E.O, Montero, M, Menendez, A, Irving, M.B, Zwick, M.B, Parren, P.W.H.I, Burton, D.R, Scott, J.K, Wilson, I.A. | Deposit date: | 2002-10-15 | Release date: | 2004-04-13 | Last modified: | 2017-06-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope To be Published
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4NUJ
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4NUG
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5VKK
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3PGF
| Crystal structure of maltose bound MBP with a conformationally specific synthetic antigen binder (sAB) | Descriptor: | GLYCEROL, IMIDAZOLE, Maltose-binding periplasmic protein, ... | Authors: | Kossiakoff, A.A, Duguid, E.M, Sandstrom, A. | Deposit date: | 2010-11-01 | Release date: | 2011-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nat.Struct.Mol.Biol., 18, 2011
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3MNW
| Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide in a helical conformation | Descriptor: | 1,2-ETHANEDIOL, ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, ... | Authors: | Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. | Deposit date: | 2010-04-22 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies To be Published
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6E4X
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4D9Q
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3MNV
| Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment | Descriptor: | 1,2-ETHANEDIOL, ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, ... | Authors: | Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F. | Deposit date: | 2010-04-22 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. Nat.Struct.Mol.Biol., 17, 2010
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6BFT
| Structure of Bevacizumab Fab mutant in complex with VEGF | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ... | Authors: | Christie, M, Christ, D. | Deposit date: | 2017-10-27 | Release date: | 2018-10-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Stable human IgG antibody therapeutics with native
framework structure To Be Published
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3CFJ
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5XRQ
| Crystal structure of human monoclonal antibody H3v-47 | Descriptor: | Fab H3v-47 heavy chain, Fab H3v-47 light chain | Authors: | Zhang, H, Willson, I.A. | Deposit date: | 2017-06-09 | Release date: | 2018-07-25 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun, 9, 2018
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3CFK
| Crystal structure of catalytic elimination antibody 34E4, triclinic crystal form | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, CATALYTIC ANTIBODY FAB 34E4 HEAVY CHAIN,Uncharacterized protein, ... | Authors: | Debler, E.W, Wilson, I.A. | Deposit date: | 2008-03-04 | Release date: | 2008-04-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Conformational isomerism can limit antibody catalysis. J.Biol.Chem., 283, 2008
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6BKC
| Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab AR3B heavy chain, Fab AR3B light chain, ... | Authors: | Tzarum, N, Wilson, I.A, Law, M. | Deposit date: | 2017-11-08 | Release date: | 2018-12-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies. Sci Adv, 5, 2019
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1HZH
| CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN | Descriptor: | IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Saphire, E.O, Burton, D.R, Wilson, I.A. | Deposit date: | 2001-01-24 | Release date: | 2001-08-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science, 293, 2001
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5VQM
| Clostridium difficile TcdB-GTD bound to PA41 Fab | Descriptor: | PA41 FAB HEAVY CHAIN, PA41 FAB LIGHT CHAIN, Toxin B | Authors: | Kroh, H.K, Spiller, B.W, Lacy, D.B. | Deposit date: | 2017-05-09 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. J. Biol. Chem., 293, 2018
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7CZQ
| S protein of SARS-CoV-2 in complex bound with P2B-1A10 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c642_heavy_IGHV3-53_IGHD1-26_IGHJ6,Chain H of P2B-1A10,Immunoglobulin gamma-1 heavy chain, ... | Authors: | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | Deposit date: | 2020-09-09 | Release date: | 2021-03-10 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
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7CZX
| S protein of SARS-CoV-2 in complex bound with P5A-1B9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c168_light_IGKV4-1_IGKJ4,Uncharacterized protein, ... | Authors: | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | Deposit date: | 2020-09-09 | Release date: | 2021-03-10 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
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6NZ7
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