4NWU
Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1
Summary for 4NWU
Entry DOI | 10.2210/pdb4nwu/pdb |
Descriptor | APE1551 Ab Fab heavy chain, APE1551 Ab Fab light chain (3 entities in total) |
Functional Keywords | beta-sandwich, human beta nerve growth factor, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P01857 |
Total number of polymer chains | 2 |
Total formula weight | 50308.71 |
Authors | Verdino, P.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2013-12-06, release date: 2014-10-22, Last modification date: 2024-04-03) |
Primary citation | Bowers, P.M.,Verdino, P.,Wang, Z.,da Silva Correia, J.,Chhoa, M.,Macondray, G.,Do, M.,Neben, T.Y.,Horlick, R.A.,Stanfield, R.L.,Wilson, I.A.,King, D.J. Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. J.Biol.Chem., 289:33557-33567, 2014 Cited by PubMed: 25320089DOI: 10.1074/jbc.M114.607176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.602 Å) |
Structure validation
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