4D9Q

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Summary for 4D9Q

• Entry DOI: 10.2210/pdb4d9q/pdb
• Related: 4D9R
• Descriptor: Factor D, Anti-Factor D, light chain, Anti-Factor D, heavy chain, ... (7 entities in total)
• Functional Keywords: factor d, complement, antibody, exosite, fab, chymotrypsin, protease, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Macaca mulatta (rhesus macaque,rhesus macaques,rhesus monkeys); More
• Cellular location: Secreted : P01857
• Total number of polymer chains: 6
• Total formula weight: 143365.77

Authors

Murray, J.M.,Wiesmann, C. (deposition date: 2012-01-11, release date: 2012-02-22, Last modification date: 2023-09-13)

• Primary citation: Katschke, K.J.,Wu, P.,Ganesan, R.,Kelley, R.F.,Mathieu, M.A.,Hass, P.E.,Murray, J.,Kirchhofer, D.,Wiesmann, C.,van Lookeren Campagne, M.; Inhibiting alternative pathway complement activation by targeting the factor d exosite.; J.Biol.Chem., 287:12886-12892, 2012; PubMed: 22362762; DOI: 10.1074/jbc.M112.345082

Experimental method

X-RAY DIFFRACTION (2.28 Å)