4D9Q
Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Factor D | polymer | 228 | 24630.1 | 2 | UniProt (F6YBP7) Pfam (PF00089) In PDB | Macaca mulatta (rhesus macaque rhesus macaques rhesus monkeys) | |
2 | D, L | Anti-Factor D, light chain | polymer | 213 | 23132.6 | 2 | UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (human) | |
3 | E, H | Anti-Factor D, heavy chain | polymer | 217 | 23086.8 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | Homo sapiens (human) | |
4 | A, B, D, E, H | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
5 | A, B, D, H, L | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
7 | water | water | 18.0 | 628 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 243 (UniProt: F6YBP7)
D, L: 1 - 104 (PDB: 4D9Q)
D, L: 105 - 213 (UniProt: Q8TCD0)
E, H: 1 - 143 (PDB: 4D9Q)
E, H: 144 - 223 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Val 47 | Leu 56 | conflict |
D, L: 105 - 213 (UniProt: Q8TCD0)
E, H: 1 - 143 (PDB: 4D9Q)
E, H: 144 - 223 (UniProt: P01857)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 141698.8 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 1667.0 | |
All* | Total formula weight | 143365.8 |