4D9Q

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Factor D	polymer	228	24630.1	2	UniProt (F6YBP7) Pfam (PF00089) In PDB	Macaca mulatta (rhesus macaque rhesus macaques rhesus monkeys)
2	D, L	Anti-Factor D, light chain	polymer	213	23132.6	2	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (human)
3	E, H	Anti-Factor D, heavy chain	polymer	217	23086.8	2	UniProt (P01857) Pfam (PF07654) In PDB	Homo sapiens (human)
4	A, B, D, E, H	GLYCEROL	non-polymer		92.1	10	Chemie (GOL)
5	A, B, D, H, L	ZINC ION	non-polymer		65.4	7	Chemie (ZN)
6	A, B	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7		water	water		18.0	628	Chemie (HOH)

Sequence modifications

A, B: 16 - 243 (UniProt: F6YBP7)

PDB	External Database	Details
Val 47	Leu 56	conflict

D, L: 1 - 104 (PDB: 4D9Q)
D, L: 105 - 213 (UniProt: Q8TCD0)
E, H: 1 - 143 (PDB: 4D9Q)
E, H: 144 - 223 (UniProt: P01857)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	141698.8
Non-Polymers*	Number of molecules	20
	Total formula weight	1667.0
All*	Total formula weight	143365.8

*Water molecules are not included.