Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4D9Q

Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006957	biological_process	complement activation, alternative pathway
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0031638	biological_process	zymogen activation
A	0046872	molecular_function	metal ion binding
A	0051604	biological_process	protein maturation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006957	biological_process	complement activation, alternative pathway
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0031638	biological_process	zymogen activation
B	0046872	molecular_function	metal ion binding
B	0051604	biological_process	protein maturation
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0019814	cellular_component	immunoglobulin complex
D	0046872	molecular_function	metal ion binding
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 301

Chain	Residue
A	ASP129
H	TYR54
A	VAL130
A	VAL162
A	LEU163
A	ASP164
A	ARG165
A	MET181
A	CYS182
A	HOH492

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	ASN222
A	LYS223
A	LYS224
L	ASP30
L	ASP31
L	ASP32
L	ZN302

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 303

Chain	Residue
A	HIS57
A	ASP61

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG150
A	PRO152
A	ASP153
A	ARG154
A	HOH500

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	SER190
A	SER195
A	THR214
A	ARG218
A	HOH515

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 301

Chain	Residue
B	ASP129
B	VAL130
B	VAL162
B	LEU163
B	ASP164
B	ARG165
B	MET181
B	CYS182
B	HOH445
E	TYR54

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 302

Chain	Residue
B	LEU135
B	LEU159
B	VAL200
B	CYS201
B	GLY202
B	GLY207

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 303

Chain	Residue
B	GLN125
B	ARG129
B	ASP129
B	GLU210
B	HOH412
B	HOH436
B	HOH437
B	HOH439

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 304

Chain	Residue
A	HIS25
A	GLU77
B	GLU131

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 305

Chain	Residue
B	ARG150
B	PRO152
B	ASP153
B	ARG154

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 301

Chain	Residue
B	ARG170
B	THR170
B	LYS224
D	ASP31
D	ASP32

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 302

Chain	Residue
D	LEU54
D	ARG55
D	GLY57
D	VAL58

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 303

Chain	Residue
A	HIS146
A	HOH407
D	ASP1

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 304

Chain	Residue
D	ASN138
E	HIS172

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 301

Chain	Residue
A	GLY202
A	HOH440
E	LYS19
E	SER71
E	LEU72
E	HOH450

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 302

Chain	Residue
E	ARG38
E	GLU46
E	ASP63
E	ARG67
E	PHE68
E	HOH485

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 301

Chain	Residue
H	GLN113
H	GLY114
H	THR115
H	LEU116
H	PRO157
H	HOH433

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN H 302

Chain	Residue
H	HIS172
L	ASN138

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN L 301

Chain	Residue
D	HOH505
L	ASP28

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN L 302

Chain	Residue
A	GOL302
L	ASP31
L	ASP32

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
D	TYR192-HIS198
E	TYR202-HIS208

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI4
Number of Residues	93
Details	Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	97
Details	Region: {"description":"CH1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)