5VQM

Clostridium difficile TcdB-GTD bound to PA41 Fab

Summary for 5VQM

• Entry DOI: 10.2210/pdb5vqm/pdb
• Descriptor: Toxin B, PA41 FAB LIGHT CHAIN, PA41 FAB HEAVY CHAIN, ... (4 entities in total)
• Functional Keywords: toxin antibody, toxin-immune system complex, toxin/immune system
• Biological source: Peptoclostridium difficile (Clostridium difficile); More
• Total number of polymer chains: 6
• Total formula weight: 223373.91

Authors

Kroh, H.K.,Spiller, B.W.,Lacy, D.B. (deposition date: 2017-05-09, release date: 2017-12-06, Last modification date: 2023-10-04)

• Primary citation: Kroh, H.K.,Chandrasekaran, R.,Zhang, Z.,Rosenthal, K.,Woods, R.,Jin, X.,Nyborg, A.C.,Rainey, G.J.,Warrener, P.,Melnyk, R.A.,Spiller, B.W.,Lacy, D.B.; A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.; J. Biol. Chem., 293:941-952, 2018; PubMed: 29180448; DOI: 10.1074/jbc.M117.813428

Experimental method

X-RAY DIFFRACTION (2.79 Å)