1ZJK
| Crystal structure of the zymogen catalytic region of human MASP-2 | Descriptor: | Mannan-binding lectin serine protease 2 | Authors: | Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P. | Deposit date: | 2005-04-29 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations J.Biol.Chem., 280, 2005
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1Z92
| structure of interleukin-2 with its alpha receptor | Descriptor: | Interleukin-2, Interleukin-2 receptor alpha chain | Authors: | Rickert, M, Wang, X.Q, Goriatcheva, N, Boulanger, M.J, Garcia, K.C. | Deposit date: | 2005-03-31 | Release date: | 2005-06-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structure of interleukin-2 complexed with its alpha receptor. Science, 308, 2005
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7JTQ
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7JTN
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3RJ3
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7KG4
| Recombinant Beta-2-Glycoprotein I antibody recognition loop mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Klenotic, P.A, Yu, E.W. | Deposit date: | 2020-10-15 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Beta-2-Glycoprotein I and its role in APS To be published
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1C1Z
| CRYSTAL STRUCTURE OF HUMAN BETA-2-GLYCOPROTEIN-I (APOLIPOPROTEIN-H) | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA2-GLYCOPROTEIN-I, ... | Authors: | Schwarzenbacher, R, Zeth, K, Diederichs, K, Gries, A, Kostner, G.M, Laggner, P, Prassl, R. | Deposit date: | 1999-07-22 | Release date: | 1999-11-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome. EMBO J., 18, 1999
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2ATY
| Complement receptor chimaeric conjugate CR2-Ig | Descriptor: | Complement receptor chimeric conjugate CR2-Ig | Authors: | Gilbert, H.E, Aslam, M, Guthridge, J.M, Holers, V.M, Perkins, S.J. | Deposit date: | 2005-08-26 | Release date: | 2006-01-31 | Last modified: | 2024-02-14 | Method: | SOLUTION SCATTERING | Cite: | Extended Flexible Linker Structures in the Complement Chimaeric Conjugate CR2-Ig by Scattering, Analytical Ultracentrifugation and Constrained Modelling: Implications for Function and Therapy. J.Mol.Biol., 356, 2006
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1ELV
| CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE | Descriptor: | 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C1S COMPONENT, ... | Authors: | Gaboriaud, C, Rossi, V, Bally, I, Arlaud, G, Fontecilla-Camps, J.-C. | Deposit date: | 2000-03-14 | Release date: | 2001-03-14 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle. EMBO J., 19, 2000
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3L89
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3O8E
| Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DITHIANE DIOL, Fiber 36.1 kDa protein, ... | Authors: | Persson, B.D, Schmitz, N.B, Casasnovas, J.M, Stehle, T. | Deposit date: | 2010-08-03 | Release date: | 2010-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. Plos Pathog., 6, 2010
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2B5I
| cytokine receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... | Authors: | Wang, X, Rickert, M, Garcia, K.C. | Deposit date: | 2005-09-28 | Release date: | 2005-11-29 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science, 310, 2005
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4AQB
| MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44 | Descriptor: | CALCIUM ION, MANNAN-BINDING LECTIN SERINE PROTEASE 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Skjoedt, M.O, Roversi, P, Hummelshoj, T, Palarasah, Y, Johnson, S, Lea, S.M, Garred, P. | Deposit date: | 2012-04-16 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Crystal Structure and Functional Characterization of the Complement Regulator Mannose-Binding Lectin (Mbl)/Ficolin-Associated Protein-1 (Map-1). J.Biol.Chem., 287, 2012
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7Y5Q
| Structure of 1:1 PAPP-A.STC2 complex(half map) | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION | Authors: | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | Deposit date: | 2022-06-17 | Release date: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov, 8, 2022
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3OED
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2ERJ
| Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Debler, E.W, Stauber, D.J, Wilson, I.A. | Deposit date: | 2005-10-25 | Release date: | 2006-02-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc.Natl.Acad.Sci.Usa, 103, 2006
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3OXU
| Complement components factor H CCP19-20 and C3d in complex | Descriptor: | Complement C3, GLYCEROL, HF protein | Authors: | Morgan, H.P, Schmidt, C.Q, Guariento, M, Gillespie, D, Herbert, A.P, Mertens, H, Blaum, B.S, Svergun, D, Johansson, C.M, Uhrin, D, Barlow, P.N, Hannan, J.P. | Deposit date: | 2010-09-22 | Release date: | 2011-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for engagement by complement factor H of C3b on a self surface. Nat.Struct.Mol.Biol., 18, 2011
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5FOA
| Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4) | Descriptor: | COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ... | Authors: | Forneris, F, Wu, J, Xue, X, Gros, P. | Deposit date: | 2015-11-18 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4.188 Å) | Cite: | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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4KKD
| The X-ray crystal structure of Mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3MC syndrome | Descriptor: | IMIDAZOLE, Mannan-binding lectin serine protease 1 | Authors: | Yongqing, T, Wilmann, P.G, Reeve, S.B, Coetzer, T.H, Smith, A.I, Whisstock, J.C, Pike, R.N, Wijeyewickrema, L.C. | Deposit date: | 2013-05-05 | Release date: | 2013-07-03 | Last modified: | 2013-08-21 | Method: | X-RAY DIFFRACTION (2.5991 Å) | Cite: | The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome. J.Biol.Chem., 288, 2013
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4JHS
| Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 | Descriptor: | Beta-2-glycoprotein 1, SULFATE ION | Authors: | Bonanno, J.B, Toro, R, Gizzi, A, Chan, M.K, Garrett-Thomson, S.C, Patel, H, Lim, S, Matikainen, B, Celikgil, A, Garforth, S, Hillerich, B, Seidel, R, Rand, J.H, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | Deposit date: | 2013-03-05 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 To be Published
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4LOS
| C1s CUB2-CCP1 | Descriptor: | CALCIUM ION, Complement C1s subcomponent heavy chain | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E, Gingras, A.R. | Deposit date: | 2013-07-13 | Release date: | 2013-08-07 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LOT
| C1s CUB2-CCP1-CCP2 | Descriptor: | Complement C1s subcomponent heavy chain | Authors: | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. | Deposit date: | 2013-07-13 | Release date: | 2013-08-07 | Last modified: | 2013-09-04 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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7DO4
| Crystal structure of CD97-CD55 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Niu, M, Song, G. | Deposit date: | 2020-12-11 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs. J.Biol.Chem., 296, 2021
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4J1Y
| The X-ray crystal structure of human complement protease C1s zymogen | Descriptor: | Complement C1s subcomponent | Authors: | Perry, A.J, Wijeyewickrema, L.C, Wilmann, P.G, Gunzburg, M.J, D'Andrea, L, Irving, J.A, Pang, S.S, Duncan, R.C, Wilce, J.A, Whisstock, J.C, Pike, R.N. | Deposit date: | 2013-02-03 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6645 Å) | Cite: | A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. J.Biol.Chem., 288, 2013
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2XQW
| Structure of Factor H domains 19-20 in complex with complement C3d | Descriptor: | COMPLEMENT C3, COMPLEMENT FACTOR H | Authors: | Kajander, T, Lehtinen, M.J, Hyvarinen, S, Bhattacharjee, A, Leung, E, Isenman, D.E, Meri, S, Jokiranta, T.S, Goldman, A. | Deposit date: | 2010-09-07 | Release date: | 2011-02-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.306 Å) | Cite: | Dual Interaction of Factor H with C3D and Glycosaminoglycans in Host-Nonhost Discrimination by Complement. Proc.Natl.Acad.Sci.USA, 108, 2011
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