7JTQ

Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases

Summary for 7JTQ

Entry DOI	10.2210/pdb7jtq/pdb
Descriptor	Complement factor B, DNA (32-MER) (2 entities in total)
Functional Keywords	complement, protease, convertase, inhibitor, aptamer, immune system, immune system-dna complex, immune system/dna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	194163.50
Authors	Xu, X.,Geisbrecht, B.V. (deposition date: 2020-08-18, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Xu, X.,Zhang, C.,Denton, D.T.,O'Connell, D.,Drolet, D.W.,Geisbrecht, B.V. Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol., 206:861-873, 2021 Cited by PubMed: 33419768 DOI: 10.4049/jimmunol.2001260 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation