4J1Y

The X-ray crystal structure of human complement protease C1s zymogen

Summary for 4J1Y

Entry DOI	10.2210/pdb4j1y/pdb
Related	1ELV
Descriptor	Complement C1s subcomponent (2 entities in total)
Functional Keywords	c4, c2, hydrolysis, extracellular, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	87532.91
Authors	Perry, A.J.,Wijeyewickrema, L.C.,Wilmann, P.G.,Gunzburg, M.J.,D'Andrea, L.,Irving, J.A.,Pang, S.S.,Duncan, R.C.,Wilce, J.A.,Whisstock, J.C.,Pike, R.N. (deposition date: 2013-02-03, release date: 2013-04-24, Last modification date: 2023-09-20)
Primary citation	Perry, A.J.,Wijeyewickrema, L.C.,Wilmann, P.G.,Gunzburg, M.J.,D'Andrea, L.,Irving, J.A.,Pang, S.S.,Duncan, R.C.,Wilce, J.A.,Whisstock, J.C.,Pike, R.N. A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. J.Biol.Chem., 288:15821-15829, 2013 Cited by PubMed: 23592783 DOI: 10.1074/jbc.M113.464545 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6645 Å)

Structure validation