5POF
 
 | | PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10941a | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 1, N-(1-benzylpiperidin-4-yl)acetamide, ... | | Authors: | Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | Deposit date: | 2017-02-07 | | Release date: | 2017-03-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
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7BV8
 | | Mature 50S ribosomal subunit from RrmJ knock out E.coli strain | | Descriptor: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | | Authors: | Wang, W, Li, W.Q, Ge, X.L, Yan, K.G, Mandava, C.S, Sanyal, S, Gao, N. | | Deposit date: | 2020-04-09 | | Release date: | 2020-07-01 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8P5D
 | | Spraguea lophii ribosome in the closed conformation by cryo sub tomogram averaging | | Descriptor: | 40S Ribosomal protein S19, 40S ribosomal protein S0, 40S ribosomal protein S10, ... | | Authors: | Gil Diez, P, McLaren, M, Isupov, M.N, Daum, B, Conners, R, Williams, B. | | Deposit date: | 2023-05-23 | | Release date: | 2023-06-21 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (10.8 Å) | | Cite: | CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state.
Nat Microbiol, 8, 2023
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8P60
 | | Spraguea lophii ribosome dimer | | Descriptor: | 40S Ribosomal protein S19, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | Authors: | Gil Diez, P, McLaren, M, Isupov, M.N, Daum, B, Conners, R, Williams, B. | | Deposit date: | 2023-05-24 | | Release date: | 2023-06-21 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (14.3 Å) | | Cite: | CryoEM reveals that ribosomes in microsporidian spores are locked in a dimeric hibernating state.
Nat Microbiol, 8, 2023
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7BHP
 | | Cryo-EM structure of the human Ebp1 - 80S ribosome | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Desogus, J, Bhaskar, V, Chao, J.A. | | Deposit date: | 2021-01-11 | | Release date: | 2021-02-03 | | Last modified: | 2021-03-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Dynamic association of human Ebp1 with the ribosome.
Rna, 27, 2021
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7BT6
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8OOS
 | | CryoEM Structure INO80core Hexasome complex ATPase-hexasome refinement state 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromatin-remodeling ATPase Ino80, DNA Strand 2, ... | | Authors: | Zhang, M, Jungblut, A, Hoffmann, T, Eustermann, S. | | Deposit date: | 2023-04-05 | | Release date: | 2023-07-26 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
Science, 381, 2023
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5T5H
 | | Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit | | Descriptor: | 40S ribosomal protein L14, 5.8S rRNA, 5S rRNA, ... | | Authors: | Liu, Z, Gutierrez-Vargas, C, Wei, J, Grassucci, R.A, Ramesh, M, Espina, N, Sun, M, Tutuncuoglu, B, Madison-Antenucci, S, Woolford Jr, J.L, Tong, L, Frank, J. | | Deposit date: | 2016-08-31 | | Release date: | 2016-10-12 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7BTQ
 | | EcoR124I-DNA in the Restriction-Alleviation State | | Descriptor: | DNA (64-MER), Type I restriction enzyme EcoR124II M protein, Type I restriction enzyme R Protein, ... | | Authors: | Gao, Y, Gao, P. | | Deposit date: | 2020-04-02 | | Release date: | 2020-05-27 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.54 Å) | | Cite: | Structural insights into assembly, operation and inhibition of a type I restriction-modification system.
Nat Microbiol, 5, 2020
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5T2X
 | | Crystal structure of Uncharacterised protein lpg1670 | | Descriptor: | Uncharacterized protein LPG1670 | | Authors: | Chang, C, Xu, X, Cui, H, SAVCHENKO, A, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2016-08-24 | | Release date: | 2016-09-28 | | Method: | X-RAY DIFFRACTION (2.303 Å) | | Cite: | Crystal structure of Uncharacterised protein lpg1670
To Be Published
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7BWN
 | | Crystal Structure of a Designed Protein Heterocatenane | | Descriptor: | Cellular tumor antigen p53, Chimera of Green fluorescent protein and p53dim | | Authors: | Liu, Y.J, Duan, Z.L, Fang, J, Zhang, F, Xiao, J.Y, Zhang, W.B. | | Deposit date: | 2020-04-15 | | Release date: | 2020-06-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane.
Angew.Chem.Int.Ed.Engl., 59, 2020
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7BTB
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7E1H
 | | crystal structure of RD-BEF | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DNA-binding response regulator, MAGNESIUM ION | | Authors: | Hong, S, Zhang, X, Zhang, P. | | Deposit date: | 2021-02-01 | | Release date: | 2022-02-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.805 Å) | | Cite: | Structural basis of phosphorylation-induced activation of the response regulator VbrR.
Acta Biochim.Biophys.Sin., 2023
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7AQR
 | | Cryo-EM structure of Arabidopsis thaliana Complex-I (peripheral arm) | | Descriptor: | Acyl carrier protein 2, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | | Deposit date: | 2020-10-22 | | Release date: | 2021-12-08 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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7AR9
 | | Cryo-EM structure of Polytomella Complex-I (membrane arm) | | Descriptor: | (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 15 kDa, AGGG, ... | | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | | Deposit date: | 2020-10-23 | | Release date: | 2021-12-08 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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5T6R
 | | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex | | Descriptor: | 25S Ribosomal RNA, 5.8S Ribosomal RNA, 5S Ribosomal RNA, ... | | Authors: | Malyutin, A.G, Musalgaonkar, S, Patchett, S, Frank, J, Johnson, A.W. | | Deposit date: | 2016-09-01 | | Release date: | 2017-02-08 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.
EMBO J., 36, 2017
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7E49
 | | Crystal structure of MIF bound to compound10 | | Descriptor: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor | | Authors: | Fan, C.P, Guo, D.Y, Yang, L. | | Deposit date: | 2021-02-11 | | Release date: | 2023-02-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.574 Å) | | Cite: | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
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3ZP4
 | | Arg90Cit chorismate mutase of Bacillus subtilis in complex with a transition state analog | | Descriptor: | 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID, CHORISMATE MUTASE AROH | | Authors: | Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. | | Deposit date: | 2013-02-26 | | Release date: | 2014-04-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4D6T
 | | Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol, CARDIOLIPIN, ... | | Authors: | Capper, M.J, O'Neill, P.M, Fisher, N, Strange, R.W, Moss, D, Ward, S.A, Berry, N.G, Lawrenson, A.S, Hasnain, S.S, Biagini, G.A, Antonyuk, S.V. | | Deposit date: | 2014-11-14 | | Release date: | 2015-01-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.57 Å) | | Cite: | Antimalarial 4(1H)-Pyridones Bind to the Qi Site of Cytochrome Bc1.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5TRR
 | | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2169 | | Descriptor: | N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-N-[(naphthalen-1-yl)methyl]-L-alaninamide, Proteasome subunit alpha, Proteasome subunit beta | | Authors: | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | | Deposit date: | 2016-10-27 | | Release date: | 2017-01-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.103 Å) | | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry, 56, 2017
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5U8S
 | | Structure of eukaryotic CMG helicase at a replication fork | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ... | | Authors: | Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E. | | Deposit date: | 2016-12-14 | | Release date: | 2017-01-25 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (6.101 Å) | | Cite: | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TRY
 | | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206 | | Descriptor: | (2~{S})-~{N}-[(2~{S})-3-methoxy-1-(naphthalen-1-ylmethylamino)-1-oxidanylidene-propan-2-yl]-4-oxidanylidene-2-(3-phenylpropanoylamino)-4-piperidin-1-yl-butanamide, Proteasome subunit alpha, Proteasome subunit beta | | Authors: | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | | Deposit date: | 2016-10-27 | | Release date: | 2017-01-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.000008 Å) | | Cite: | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry, 56, 2017
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4D6U
 | | Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol, CARDIOLIPIN, ... | | Authors: | Capper, M.J, ONeill, P.M, Fisher, N, Strange, R.W, Moss, D, Ward, S.A, Berry, N.G, Lawrenson, A.S, Hasnain, S.S, Biagini, G.A, Antonyuk, S.V. | | Deposit date: | 2014-11-14 | | Release date: | 2015-01-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (4.09 Å) | | Cite: | Antimalarial 4(1H)-Pyridones Bind to the Qi Site of Cytochrome Bc1.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5ME0
 | | Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112 | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S. | | Deposit date: | 2016-11-14 | | Release date: | 2017-01-11 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
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5MQF
 | | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX8, Cell division cycle 5-like protein, ... | | Authors: | Bertram, K, Hartmuth, K, Kastner, B. | | Deposit date: | 2016-12-20 | | Release date: | 2017-03-22 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature, 542, 2017
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