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5TRR

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2169

Summary for 5TRR
Entry DOI10.2210/pdb5trr/pdb
Related5TRG 5TRS 5TRY 5TS0
Related PRD IDPRD_002255
DescriptorProteasome subunit alpha, Proteasome subunit beta, N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-N-[(naphthalen-1-yl)methyl]-L-alaninamide, ... (4 entities in total)
Functional Keywordsn, c-capped dipeptides, mycobacterium tuberculosis, proteasome inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceMycobacterium tuberculosis
More
Total number of polymer chains28
Total formula weight724876.56
Authors
Hsu, H.-C.,Fan, H.,Singh, P.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-27, release date: 2017-01-11, Last modification date: 2023-10-04)
Primary citationHsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.
Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry, 56:324-333, 2017
Cited by
PubMed: 27976853
DOI: 10.1021/acs.biochem.6b01107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.103 Å)
Structure validation

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