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8PI4	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in dimer (T2) conformation Descriptor: Insulin B chain,Insulin A chain Authors: Johansson, E, Schluckebier, G. Deposit date: 2023-06-21 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PI6	Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension Descriptor: Insulin B chain,Insulin A chain Authors: Johansson, E, Schluckebier, G. Deposit date: 2023-06-21 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PI5	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in hexamer (T3R3) conformation Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, RESORCINOL, ... Authors: Johansson, E, Schluckebier, G. Deposit date: 2023-06-21 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PJH	Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation Descriptor: Insulin Authors: Schluckebier, G, Johansson, E. Deposit date: 2023-06-23 Release date: 2023-11-08 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
6U46	Solution Structure of a Heat-Resistant Long-Acting Insulin Analog Descriptor: Insulin Authors: Yang, Y, Weiss, M.A. Deposit date: 2019-08-23 Release date: 2020-08-26 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution Structure of a Heat-Resistant Long-Acting Insulin Analog To Be Published
1QJ0	HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. Deposit date: 1999-06-18 Release date: 1999-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
1QIY	HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G. Deposit date: 1999-06-18 Release date: 1999-06-22 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis. Biochemistry, 38, 1999
1RWE	Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2003-12-16 Release date: 2005-02-15 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry, 43, 2004
3GF1	SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY Descriptor: INSULIN-LIKE GROWTH FACTOR I Authors: Cooke, R.M, Harvey, T.S, Campbell, I.D. Deposit date: 1991-01-24 Release date: 1993-04-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30, 1991
4IYD	Insulin glargine crystal structure 1 Descriptor: Insulin A chain, Insulin B chain Authors: Barba de la Rosa, A.P, Lara-Gonzalez, S, Montero-Moran, G.M, Escobedo-Moratilla, A. Deposit date: 2013-01-28 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Physicochemical and structural analysis of a biosimilar insulin glargine formulation and its reference to be published
3GKY	The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. Deposit date: 2009-03-11 Release date: 2009-03-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284, 2009
4IUZ	High resolution crystal structure of racemic ester insulin Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... Authors: Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. Deposit date: 2013-01-22 Release date: 2013-02-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography. J.Am.Chem.Soc., 135, 2013
4IYF	Insulin glargine crystal structure 2 Descriptor: Insulin A chain, Insulin B chain Authors: Barba de la Rosa, A.P, Lara-Gonzalez, S, Montero-Moran, G.M, Escobedo-Moratilla, A. Deposit date: 2013-01-28 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Physicochemical and structural analysis of a biosimilar insulin glargine formulation and its reference to be published
2BN1	Insulin after a high dose x-ray burn Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Nanao, M.H, Ravelli, R.B. Deposit date: 2005-03-18 Release date: 2005-09-07 Last modified: 2013-04-03 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
6INS	X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE Descriptor: INSULIN, ZINC ION Authors: Derewenda, U, Derewenda, Z, Dodson, E.J, Dodson, G.G, Bing, X, Markussen, J. Deposit date: 1992-11-25 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue. J.Mol.Biol., 220, 1991
2BN3	Insulin before a high dose x-ray burn Descriptor: INSULIN Authors: Nanao, M.H, Ravelli, R.B. Deposit date: 2005-03-18 Release date: 2005-09-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
6JR3	Crystal structure of insulin hexamer fitted into cryo EM density map where each dimer was kept as rigid body Descriptor: Insulin A chain, Insulin B chain Authors: Sengupta, J, Pathak, B.K, Bhakta, S. Deposit date: 2019-04-02 Release date: 2020-04-22 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (14.5 Å) Cite: Resveratrol as a nontoxic excipient stabilizes insulin in a bioactive hexameric form. J.Comput.Aided Mol.Des., 34, 2020
2C8R	insuline(60sec) and UV laser excited fluorescence Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D. Deposit date: 2005-12-06 Release date: 2006-03-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops. Acta Crystallogr.,Sect.D, 62, 2006
2C8Q	insuline(1sec) and UV laser excited fluorescence Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D. Deposit date: 2005-12-06 Release date: 2006-03-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops. Acta Crystallogr.,Sect.D, 62, 2006
3INC	Crystal structure of human insulin with Ni+2 complex Descriptor: Insulin A chain, Insulin B chain, NICKEL (II) ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-12 Release date: 2010-08-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
3INS	STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B), ZINC ION Authors: Wlodawer, A, Savage, H. Deposit date: 1988-10-14 Release date: 1989-01-09 Last modified: 2017-11-29 Method: NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION Cite: Structure of insulin: results of joint neutron and X-ray refinement. Acta Crystallogr.,Sect.B, 45, 1989
3IR0	Crystal Structure of Human Insulin complexed with Cu+2 metal ion Descriptor: COPPER (II) ION, Insulin A chain, Insulin B chain Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Metal induced structural changes observed in Human insulin To be Published
3ILG	Crystal structure of humnan insulin Sr+2 complex Descriptor: Insulin A chain, Insulin B chain, STRONTIUM ION Authors: Raghavendra, N, Pattabhi, V, Rajan, S.S. Deposit date: 2009-08-07 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Metal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin To be Published
2EFA	Neutron crystal structure of cubic insulin at pD6.6 Descriptor: Insulin Authors: Ishikawa, T, Tanaka, I, Niimura, N. Deposit date: 2007-02-22 Release date: 2008-01-22 Last modified: 2023-10-25 Method: NEUTRON DIFFRACTION (2.7 Å) Cite: A neutron crystallographic analysis of a cubic porcine insulin at pD 6.6 Chem.Phys., 345, 2008
6K59	Structure of Glargine insulin in 20% acetic acid-d4 (pH 1.9) Descriptor: Glargine Insulin Chain-A, Glargine insulin Chain-B Authors: Ratha, B.N, Kar, R.K, Bhunia, A. Deposit date: 2019-05-28 Release date: 2020-05-06 Method: SOLUTION NMR Cite: Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis. J.Phys.Chem.B, 124, 2020

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