High resolution crystal structure of racemic ester insulin

Summary for 4IUZ

DescriptorInsulin A chain, Insulin B chain, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywordsracemic protein crystallography, dkp ester insulin, hormone precursor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight6098.93
Avital-Shmilovici, M.,Mandal, K.,Gates, Z.P.,Phillips, N.,Weiss, M.A.,Kent, S.B.H. (deposition date: 2013-01-22, release date: 2013-02-13, Last modification date: 2013-03-20)
Primary citation
Avital-Shmilovici, M.,Mandal, K.,Gates, Z.P.,Phillips, N.B.,Weiss, M.A.,Kent, S.B.
Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography.
J.Am.Chem.Soc., 135:3173-3185, 2013
PubMed: 23343390 (PDB entries with the same primary citation)
DOI: 10.1021/ja311408y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2481706.7%13.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report