8RRP

Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin

Summary for 8RRP

Entry DOI	10.2210/pdb8rrp/pdb
Descriptor	Insulin, Insulin B chain, ACETATE ION, ... (4 entities in total)
Functional Keywords	insulin, hormone
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	17063.39
Authors	Schluckebier, G.,Johansson, E. (deposition date: 2024-01-23, release date: 2024-07-10, Last modification date: 2024-07-31)
Primary citation	Hubalek, F.,Cramer, C.N.,Helleberg, H.,Johansson, E.,Nishimura, E.,Schluckebier, G.,Steensgaard, D.B.,Sturis, J.,Kjeldsen, T.B. Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec. Nat Commun, 15:6124-6124, 2024 Cited by PubMed: 39033137 DOI: 10.1038/s41467-024-50477-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation