8RRP

Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Insulin	polymer	21	2349.6	3	UniProt (P01308)	Homo sapiens (human)
2	B, D, F (B, D, F)	Insulin B chain	polymer	29	3298.8	3	UniProt (P01308) Pfam (PF00049)	Homo sapiens (human)
3	G, H (B, D)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	50	Chemie (HOH)

Sequence modifications

A, C, E: 1 - 21 (UniProt: P01308)

PDB	External Database	Details
Glu 14	Tyr 103	engineered mutation

B, D, F: 1 - 29 (UniProt: P01308)

PDB	External Database	Details
His 16	Tyr 40	engineered mutation
His 25	Phe 49	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	16945.3
Non-Polymers*	Number of molecules	2
	Total formula weight	118.1
All*	Total formula weight	17063.4

*Water molecules are not included.