6PX5
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![BU of 6px5 by Molmil](/molmil-images/mine/6px5) | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | Authors: | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | Deposit date: | 2019-07-24 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Sci Rep, 9, 2019
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1NL2
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![BU of 1nl2 by Molmil](/molmil-images/mine/1nl2) | BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM AND LYSOPHOSPHOTIDYLSERINE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huang, M, Huang, G, Furie, B, Seaton, B, Furie, B.C. | Deposit date: | 2003-01-06 | Release date: | 2003-09-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat.Struct.Biol., 10, 2003
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2DOI
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![BU of 2doi by Molmil](/molmil-images/mine/2doi) | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcus protein PAM | Descriptor: | Angiostatin, Plasminogen-binding group A streptococcal M-like protein PAM | Authors: | Cnudde, S.E, Prorok, M, Castellino, F.J, Geiger, J.H. | Deposit date: | 2006-04-29 | Release date: | 2006-12-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM Biochemistry, 45, 2006
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2DOH
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![BU of 2doh by Molmil](/molmil-images/mine/2doh) | The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Angiostatin, Plasminogen-binding group A streptococcal M-like protein PAM | Authors: | Cnudde, S.E, Prorok, M, Castellino, F.J, Geiger, J.H. | Deposit date: | 2006-04-29 | Release date: | 2006-12-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM Biochemistry, 45, 2006
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7ME4
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![BU of 7me4 by Molmil](/molmil-images/mine/7me4) | Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2 | Authors: | Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A. | Deposit date: | 2021-04-06 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Rep, 37, 2021
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1I5K
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![BU of 1i5k by Molmil](/molmil-images/mine/1i5k) | STRUCTURE AND BINDING DETERMINANTS OF THE RECOMBINANT KRINGLE-2 DOMAIN OF HUMAN PLASMINOGEN TO AN INTERNAL PEPTIDE FROM A GROUP A STREPTOCOCCAL SURFACE PROTEIN | Descriptor: | M PROTEIN, PLASMINOGEN | Authors: | Rios-Steiner, J.L, Schenone, M, Mochalkin, I, Tulinsky, A, Castellino, F.J. | Deposit date: | 2001-02-27 | Release date: | 2001-08-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. J.Mol.Biol., 308, 2001
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2HPP
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![BU of 2hpp by Molmil](/molmil-images/mine/2hpp) | |
2HPQ
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![BU of 2hpq by Molmil](/molmil-images/mine/2hpq) | |
5EDM
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![BU of 5edm by Molmil](/molmil-images/mine/5edm) | Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I ) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Pozzi, N, Chen, Z, Di Cera, E. | Deposit date: | 2015-10-21 | Release date: | 2016-01-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
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5EDK
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![BU of 5edk by Molmil](/molmil-images/mine/5edk) | Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | Authors: | Pozzi, N, Chen, Z, Di Cera, E. | Deposit date: | 2015-10-21 | Release date: | 2016-01-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.214 Å) | Cite: | How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
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3HN4
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![BU of 3hn4 by Molmil](/molmil-images/mine/3hn4) | |
8OS5
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![BU of 8os5 by Molmil](/molmil-images/mine/8os5) | Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction | Descriptor: | Coagulation factor XII-Mie | Authors: | Li, C, Saleem, M, Kaira, B.G, Brown, A, Wilson, C, Philippou, H, Emsley, J. | Deposit date: | 2023-04-18 | Release date: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood, 136, 2020
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9CTH
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![BU of 9cth by Molmil](/molmil-images/mine/9cth) | Preliminary map of the Prothrombin-prothrombinase complex on nano discs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated Factor V (FVa) heavy chain, Activated Factor V (FVa) light chain, ... | Authors: | Stojanovski, B.M, Mohammed, B.M, Di Cera, E. | Deposit date: | 2024-07-25 | Release date: | 2024-08-07 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (6.47 Å) | Cite: | The Prothrombin-Prothrombinase Interaction. Subcell Biochem, 104, 2024
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4D3C
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![BU of 4d3c by Molmil](/molmil-images/mine/4d3c) | |
7TPP
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![BU of 7tpp by Molmil](/molmil-images/mine/7tpp) | |
3SP8
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![BU of 3sp8 by Molmil](/molmil-images/mine/3sp8) | Crystal structure of NK2 in complex with fractionated Heparin DP10 | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Recacha, R, Mulloy, B, Gherardi, E. | Deposit date: | 2011-07-01 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of NK2 in complex with fractionated Heparin DP10 TO BE PUBLISHED
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4DUR
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![BU of 4dur by Molmil](/molmil-images/mine/4dur) | The X-ray Crystal Structure of Full-Length type II Human Plasminogen | Descriptor: | ACETATE ION, BICARBONATE ION, CHLORIDE ION, ... | Authors: | Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C. | Deposit date: | 2012-02-22 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The X-ray crystal structure of full-length human plasminogen Cell Rep, 1, 2012
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4DUU
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3U73
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![BU of 3u73 by Molmil](/molmil-images/mine/3u73) | Crystal structure of stabilized human uPAR mutant in complex with ATF | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ... | Authors: | Huang, M.D, Xu, X, Yuan, C. | Deposit date: | 2011-10-13 | Release date: | 2012-04-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Crystal structure of the urokinase receptor in a ligand-free form. J.Mol.Biol., 416, 2012
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3BT2
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![BU of 3bt2 by Molmil](/molmil-images/mine/3bt2) | Structure of urokinase receptor, urokinase and vitronectin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ... | Authors: | Huang, M. | Deposit date: | 2007-12-27 | Release date: | 2008-03-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes Nat.Struct.Mol.Biol., 15, 2008
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3BT1
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![BU of 3bt1 by Molmil](/molmil-images/mine/3bt1) | Structure of urokinase receptor, urokinase and vitronectin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, ... | Authors: | Huang, M. | Deposit date: | 2007-12-27 | Release date: | 2008-03-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes Nat.Struct.Mol.Biol., 15, 2008
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1BHT
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![BU of 1bht by Molmil](/molmil-images/mine/1bht) | NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR, SULFATE ION | Authors: | Ultsch, M.H, Lokker, N.A, Godowski, P.J, De Vos, A.M. | Deposit date: | 1998-06-10 | Release date: | 1998-11-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. Structure, 6, 1998
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3LAQ
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![BU of 3laq by Molmil](/molmil-images/mine/3laq) | Structure-based engineering of species selectivity in the uPA-uPAR interaction | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator | Authors: | Huang, M. | Deposit date: | 2010-01-06 | Release date: | 2010-02-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J.Biol.Chem., 285, 2010
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4IUA
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![BU of 4iua by Molmil](/molmil-images/mine/4iua) | Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor, SULFATE ION | Authors: | Tolbert, W.D, Zhou, E, Kovach, A, Melcher, K, Xu, H.E. | Deposit date: | 2013-01-20 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal Structure of the NK2 Fragment of the mouse Hepatocyte Growth Factor/Scatter Factor To be Published
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4K24
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![BU of 4k24 by Molmil](/molmil-images/mine/4k24) | Structure of anti-uPAR Fab ATN-658 in complex with uPAR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ... | Authors: | Huang, M.D, Xu, X, Yuan, C. | Deposit date: | 2013-04-08 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M) Plos One, 9, 2014
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