7ME4

Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk

Summary for 7ME4

• Entry DOI: 10.2210/pdb7me4/pdb
• Descriptor: Tyrosine-protein kinase transmembrane receptor Ror2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, ... (4 entities in total)
• Functional Keywords: wnt signaling, receptor tyrosine kinases, acylation, growth factor signaling, co-receptor, pseudokinases, ligand, receptor, cancer, signaling protein
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 1
• Total formula weight: 33266.45

Authors

Mendrola, J.M.,Shi, F.,Perry, K.,Stayrook, S.E.,Lemmon, M.A. (deposition date: 2021-04-06, release date: 2021-10-13, Last modification date: 2023-10-18)

• Primary citation: Shi, F.,Mendrola, J.M.,Sheetz, J.B.,Wu, N.,Sommer, A.,Speer, K.F.,Noordermeer, J.N.,Kan, Z.Y.,Perry, K.,Englander, S.W.,Stayrook, S.E.,Fradkin, L.G.,Lemmon, M.A.; ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.; Cell Rep, 37:109834-109834, 2021; PubMed: 34686333; DOI: 10.1016/j.celrep.2021.109834

Experimental method

X-RAY DIFFRACTION (1.75 Å)