8OS5
Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction
Summary for 8OS5
| Entry DOI | 10.2210/pdb8os5/pdb |
| Descriptor | Coagulation factor XII-Mie (1 entity in total) |
| Functional Keywords | factor xii heavy chain crystal structure thrombosis kringle domain, blood clotting |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 100503.13 |
| Authors | Li, C.,Saleem, M.,Kaira, B.G.,Brown, A.,Wilson, C.,Philippou, H.,Emsley, J. (deposition date: 2023-04-18, release date: 2024-03-27) |
| Primary citation | Kaira, B.G.,Slater, A.,McCrae, K.R.,Dreveny, I.,Sumya, U.,Mutch, N.J.,Searle, M.,Emsley, J. Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood, 136:1685-1697, 2020 Cited by PubMed: 32559765DOI: 10.1182/blood.2020004818 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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