8OS5
Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00021 |
| Number of Residues | 13 |
| Details | KRINGLE_1 Kringle domain signature. FCRNpdndirp.WC |
| Chain | Residue | Details |
| A | PHE246-CYS258 |
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. ClCpqHltGNhC |
| Chain | Residue | Details |
| A | CYS100-CYS111 | |
| A | CYS179-CYS190 |
| site_id | PS00023 |
| Number of Residues | 42 |
| Details | FN2_1 Fibronectin type-II collagen-binding domain signature. ChfPFqYhrqlyhkCthkgrpgpqpWCattpNFdqdqrWgYC |
| Chain | Residue | Details |
| A | CYS28-CYS69 |
| site_id | PS01186 |
| Number of Residues | 12 |
| Details | EGF_2 EGF-like domain signature 2. ChCpvGYtgpf....C |
| Chain | Residue | Details |
| A | CYS179-CYS190 |
| site_id | PS01253 |
| Number of Residues | 36 |
| Details | FN1_1 Fibronectin type-I domain signature. CfepqllrfFhkneiWyRteqaavar..CqCkgpdah...C |
| Chain | Residue | Details |
| A | CYS116-CYS151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI4 |
| Number of Residues | 234 |
| Details | Domain: {"description":"Kringle","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"O-linked (Fuc) threonine","evidences":[{"source":"PubMed","id":"1544894","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3877053","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3886654","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
