4D3C

Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68.

Summary for 4D3C

DescriptorHEPATOCYTE GROWTH FACTOR, SFN68 FAB, ... (4 entities in total)
Functional Keywordsprotein binding
Biological sourceHOMO SAPIENS (HUMAN)
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Total number of polymer chains3
Total molecular weight68447.68
Authors
Kang, Y.J.,Kim, K.L.,Cho, H.S.,Chung, J.H. (deposition date: 2014-10-21, release date: 2016-01-13, Last modification date: 2018-08-29)
Primary citation
Kang, Y.J.,Kim, K.L.,Cho, H.S.,Chung, J.H.
A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.
to be published,
Experimental method
X-RAY DIFFRACTION (2.62 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.295904.2%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4d3c
no rotation
Molmil generated image of 4d3c
rotated about x axis by 90°
Molmil generated image of 4d3c
rotated about y axis by 90°