4D3C
Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HEPATOCYTE GROWTH FACTOR | polymer | 193 | 22242.4 | 1 | UniProt (P14210) Pfam (PF00024) Pfam (PF00051) | HOMO SAPIENS (HUMAN) | HEPATOPOIETIN-A, SCATTER FACTOR, SF, NK1 |
| 2 | B (H) | SFN68 FAB | polymer | 218 | 23231.0 | 1 | ORYCTOLAGUS CUNICULUS (RABBIT) | ||
| 3 | C (L) | SFN68 FAB | polymer | 215 | 22974.4 | 1 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (U3KM01) UniProt (by SIFTS) (P01834) | ORYCTOLAGUS CUNICULUS (RABBIT) | |
| 4 | D, E, F (A, H, L) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 32 - 210 (UniProt: P14210)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | expression tag |
| Gly 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Ser 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Gln 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Gly 134 | Arg 134 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68447.7 | |
| All* | Total formula weight | 68447.7 |
