3LAQ
Structure-based engineering of species selectivity in the uPA-uPAR interaction
Summary for 3LAQ
Entry DOI | 10.2210/pdb3laq/pdb |
Related | 2FAT 2FD6 3BT1 3BT2 |
Descriptor | Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | upa, upar, atf, supar, smupar, matf, disulfide bond, egf-like domain, hydrolase, kringle, plasminogen activation, protease, secreted, serine protease, zymogen, cell membrane, glycoprotein, gpi-anchor, lipoprotein, membrane, receptor, hydrolase-hydrolase receptor complex, hydrolase/hydrolase receptor |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 92549.57 |
Authors | Huang, M. (deposition date: 2010-01-06, release date: 2010-02-02, Last modification date: 2020-07-29) |
Primary citation | Lin, L.,Gardsvoll, H.,Huai, Q.,Huang, M.,Ploug, M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J.Biol.Chem., 285:10982-10992, 2010 Cited by PubMed: 20133942DOI: 10.1074/jbc.M109.093492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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