3LAQ

Structure-based engineering of species selectivity in the uPA-uPAR interaction

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0001934	biological_process	positive regulation of protein phosphorylation
U	0005102	molecular_function	signaling receptor binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005886	cellular_component	plasma membrane
U	0009897	cellular_component	external side of plasma membrane
U	0009986	cellular_component	cell surface
U	0010755	biological_process	regulation of plasminogen activation
U	0019899	molecular_function	enzyme binding
U	0019904	molecular_function	protein domain specific binding
U	0030155	biological_process	regulation of cell adhesion
U	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
U	0038195	biological_process	urokinase plasminogen activator signaling pathway
U	0043066	biological_process	negative regulation of apoptotic process
U	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
U	0051917	biological_process	regulation of fibrinolysis
U	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
U	0098552	cellular_component	side of membrane
U	0098637	cellular_component	protein complex involved in cell-matrix adhesion
U	1905370	cellular_component	serine-type endopeptidase complex
U	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
U	2001268	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
V	0001934	biological_process	positive regulation of protein phosphorylation
V	0005102	molecular_function	signaling receptor binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005886	cellular_component	plasma membrane
V	0009897	cellular_component	external side of plasma membrane
V	0009986	cellular_component	cell surface
V	0010755	biological_process	regulation of plasminogen activation
V	0019899	molecular_function	enzyme binding
V	0019904	molecular_function	protein domain specific binding
V	0030155	biological_process	regulation of cell adhesion
V	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
V	0038195	biological_process	urokinase plasminogen activator signaling pathway
V	0043066	biological_process	negative regulation of apoptotic process
V	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
V	0051917	biological_process	regulation of fibrinolysis
V	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
V	0098552	cellular_component	side of membrane
V	0098637	cellular_component	protein complex involved in cell-matrix adhesion
V	1905370	cellular_component	serine-type endopeptidase complex
V	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
V	2001268	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	13
Details	KRINGLE_1 Kringle domain signature. YCRNpdnqkrp.WC

Chain	Residue	Details
A	TYR102-CYS114

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCprKfqGEhC

Chain	Residue	Details
A	CYS32-CYS43

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site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. QCMqCesnqs...Clve.....ECAlgqdlCrttvlrewqddrelevvtrg....C

Chain	Residue	Details
U	GLN2-CYS45
U	GLU95-CYS145
U	GLN191-CYS245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	LIPID: GPI-anchor amidated glycine => ECO:0000255

Chain	Residue	Details
U	GLY275
V	GLY275

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
U	ASN9
U	ASN160
U	ASN198
U	ASN231
V	ASN9
V	ASN160
V	ASN198
V	ASN231

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20133942

Chain	Residue	Details
U	ASN52
U	ASN170
U	ASN259
V	ASN52
V	ASN170
V	ASN259

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