2FD6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

Summary for 2FD6

• Entry DOI: 10.2210/pdb2fd6/pdb
• Related: 2fat
• Descriptor: Urokinase-type plasminogen activator, TRIETHYLENE GLYCOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: upar, atf, atn-615 antibody, fab, ternary complex, immune system, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 92831.71

Authors

Huang, M.,Huai, Q.,Li, Y. (deposition date: 2005-12-13, release date: 2006-02-21, Last modification date: 2024-11-20)

Primary citation

Huai, Q.,Mazar, A.P.,Kuo, A.,Parry, G.C.,Shaw, D.E.,Callahan, J.,Li, Y.,Yuan, C.,Bian, C.,Chen, L.,Furie, B.,Furie, B.C.,Cines, D.B.,Huang, M.
Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311:656-659, 2006

PubMed Abstract: The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.

PubMed: 16456079
DOI: 10.1126/science.1121143

Experimental method

X-RAY DIFFRACTION (1.9 Å)