2FD6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0002250	biological_process	adaptive immune response
H	0019814	cellular_component	immunoglobulin complex
L	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	13
Details	KRINGLE_1 Kringle domain signature. YCRNpdnrrrp.WC

Chain	Residue	Details
A	TYR101-CYS113

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCpkKfgGQhC

Chain	Residue	Details
A	CYS31-CYS42

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

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site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. RCMqCktngd...Crve.....ECAlgqdlCrttivrlweegeelelveks....C

Chain	Residue	Details
U	ARG2-CYS45
U	GLU94-CYS147
U	GLN193-CYS247

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by U-PA

Chain	Residue	Details
U	ALA84
U	SER90

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15861141, ECO:0000269|PubMed:16456079, ECO:0000269|PubMed:22285761

Chain	Residue	Details
U	ARG53

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15861141

Chain	Residue	Details
U	ASP163
U	GLN234

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15861141, ECO:0000269|PubMed:16456079

Chain	Residue	Details
U	THR173

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22285761

Chain	Residue	Details
U	SER201

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