2FD6
Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 122 | 13892.8 | 1 | UniProt (P00749) Pfam (PF00051) | Homo sapiens (human) | |
| 2 | B (L) | L chain of Fab of ATN-615 anti-uPAR antibody | polymer | 214 | 23437.9 | 1 | UniProt (Q52L64) Pfam (PF07686) Pfam (PF07654) | Mus musculus (house mouse) | |
| 3 | C (H) | H chain of Fab of ATN-615 anti-uPAR antibody | polymer | 213 | 22984.7 | 1 | UniProt (Q4V9V8) Pfam (PF07686) UniProt (by SIFTS) (Q924Q0) | Mus musculus (house mouse) | |
| 4 | D (U) | Urokinase plasminogen activator surface receptor | polymer | 276 | 30668.4 | 1 | UniProt (Q03405) Pfam (PF00021) | Homo sapiens (human) | uPAR, U-PAR, Monocyte activation antigen Mo3, CD87 antigen |
| 5 | E (B) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | H, J, K (L, H) | 2-ETHOXYETHANOL | non-polymer | 90.1 | 3 | Chemie (ETX) | |||
| 9 | I, L (L, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 10 | M (H) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 11 | N (U) | 2-acetamido-2-deoxy-alpha-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NDG) | |||
| 12 | O (U) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 13 | P, Q, R, S (A, L, H, U) | water | water | 18.0 | 336 | Chemie (HOH) |
Sequence modifications
U: 2 - 275 (UniProt: Q03405)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 90983.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 791.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1056.2 | |
| All* | Total formula weight | 92831.7 |
