5EDM

Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I )

Summary for 5EDM

Related4O03
DescriptorProthrombin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordsprothrombin, kringle, protease, coagulation factor, enzyme mechanism, kinetics, structure-function, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight67011.68
Authors
Pozzi, N.,Chen, Z.,Di Cera, E. (deposition date: 2015-10-21, release date: 2016-01-20, Last modification date: 2020-07-29)
Primary citation
Pozzi, N.,Chen, Z.,Di Cera, E.
How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
J.Biol.Chem., 291:6071-6082, 2016
PubMed: 26763231 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.700401
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2383 0.6% 4.5% 7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-09-23