7PW5
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7PW7
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![BU of 7pw7 by Molmil](/molmil-images/mine/7pw7) | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Langer, L.M, Conti, E. | Deposit date: | 2021-10-06 | Release date: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
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7PW6
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![BU of 7pw6 by Molmil](/molmil-images/mine/7pw6) | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, INOSITOL HEXAKISPHOSPHATE, Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1 | Authors: | Langer, L.M, Conti, E. | Deposit date: | 2021-10-06 | Release date: | 2021-12-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
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7C1D
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6BBP
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![BU of 6bbp by Molmil](/molmil-images/mine/6bbp) | Model for compact volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A 6GS Arf6 Q67L fusion protein | Descriptor: | Cytohesin-3,ADP-ribosylation factor 6, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... | Authors: | Das, S, Malaby, A.W, Lambright, D.G. | Deposit date: | 2017-10-19 | Release date: | 2018-01-10 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (35 Å) | Cite: | Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. Structure, 26, 2018
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6BBQ
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![BU of 6bbq by Molmil](/molmil-images/mine/6bbq) | Model for extended volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399) E161A Arf6 Q67L fusion protein | Descriptor: | Cytohesin-3,ADP-ribosylation factor 6, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... | Authors: | Das, S, Malaby, A.W, Lambright, D.G. | Deposit date: | 2017-10-19 | Release date: | 2018-01-10 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (35 Å) | Cite: | Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. Structure, 26, 2018
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6BCX
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![BU of 6bcx by Molmil](/molmil-images/mine/6bcx) | mTORC1 structure refined to 3.0 angstroms | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | Authors: | Pavletich, N.P, Yang, H. | Deposit date: | 2017-10-20 | Release date: | 2017-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
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6BCU
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7EMF
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![BU of 7emf by Molmil](/molmil-images/mine/7emf) | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | Descriptor: | Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ... | Authors: | Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. | Deposit date: | 2021-04-13 | Release date: | 2021-05-05 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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5JXS
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5ZO6
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6BQI
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![BU of 6bqi by Molmil](/molmil-images/mine/6bqi) | Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action | Descriptor: | Protein IMPACT homolog | Authors: | Harjes, E, Jameson, G.B, Edwards, P.J.B, Goroncy, A.K, Loo, T, Norris, G.E. | Deposit date: | 2017-11-27 | Release date: | 2018-11-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR, SOLUTION SCATTERING | Cite: | Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2. Febs Lett., 2020
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3VHX
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![BU of 3vhx by Molmil](/molmil-images/mine/3vhx) | The crystal structure of Arf6-MKLP1 (Mitotic kinesin-like protein 1) complex | Descriptor: | ADP-ribosylation factor 6, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Makyio, H, Takei, T, Ohgi, H, Takahashi, S, Takatsu, H, Ueda, T, Kanaho, Y, Xie, Y, Shin, H.W, Kamikubo, H, Kataoka, M, Kawasaki, M, Kato, R, Wakatsuki, S, Nakayama, K. | Deposit date: | 2011-09-12 | Release date: | 2012-05-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis Embo J., 31, 2012
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7F8J
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![BU of 7f8j by Molmil](/molmil-images/mine/7f8j) | Cryo-EM structure of human pannexin-1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8O
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![BU of 7f8o by Molmil](/molmil-images/mine/7f8o) | Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8N
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![BU of 7f8n by Molmil](/molmil-images/mine/7f8n) | Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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6CU7
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![BU of 6cu7 by Molmil](/molmil-images/mine/6cu7) | Alpha Synuclein fibril formed by full length protein - Rod Polymorph | Descriptor: | Alpha-synuclein | Authors: | Li, B, Hatami, A, Ge, P, Murray, K.A, Sheth, P, Zhang, M, Nair, G, Sawaya, M.R, Zhu, C, Broad, M, Shin, W.S, Ye, S, John, V, Eisenberg, D.S, Zhou, Z.H, Jiang, L. | Deposit date: | 2018-03-23 | Release date: | 2018-09-12 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun, 9, 2018
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7T3A
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![BU of 7t3a by Molmil](/molmil-images/mine/7t3a) | GATOR1-RAG-RAGULATOR - Inhibitory Complex | Descriptor: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | Authors: | Egri, S.B, Shen, K. | Deposit date: | 2021-12-07 | Release date: | 2022-04-06 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3B
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![BU of 7t3b by Molmil](/molmil-images/mine/7t3b) | GATOR1-RAG-RAGULATOR - GAP Complex | Descriptor: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | Authors: | Egri, S.B, Shen, K. | Deposit date: | 2021-12-07 | Release date: | 2022-04-06 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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6EHA
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![BU of 6eha by Molmil](/molmil-images/mine/6eha) | Heme oxygenase 1 in complex with inhibitor | Descriptor: | 1-(3-imidazol-1-ylpropyl)-5-(2-methylpropyl)-4-phenyl-imidazole, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Grudnik, P, Mieczkowski, M. | Deposit date: | 2017-09-12 | Release date: | 2018-10-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment. Arch.Biochem.Biophys., 671, 2019
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2SPC
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![BU of 2spc by Molmil](/molmil-images/mine/2spc) | CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN | Descriptor: | SPECTRIN | Authors: | Yan, Y, Winograd, E, Viel, A, Cronin, T, Harrison, S.C, Branton, D. | Deposit date: | 1994-03-01 | Release date: | 1994-05-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the repetitive segments of spectrin. Science, 262, 1993
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6Z3R
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![BU of 6z3r by Molmil](/molmil-images/mine/6z3r) | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Langer, L.M, Gat, Y, Conti, E. | Deposit date: | 2020-05-21 | Release date: | 2020-06-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife, 9, 2020
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5X6V
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![BU of 5x6v by Molmil](/molmil-images/mine/5x6v) | Crystal structure of human heteroheptameric complex | Descriptor: | ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | Authors: | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | Deposit date: | 2017-02-23 | Release date: | 2017-12-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
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1AIN
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1AGI
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