7C1D

Cryo-EM structure of the hE46K cross-seeded hWT alpha-synuclein fibril

Summary for 7C1D

• Entry DOI: 10.2210/pdb7c1d/pdb
• EMDB information: 30269
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: amyloid fibril, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 86856.65

Authors

Sun, Y.P.,Zhao, K.,Liu, C. (deposition date: 2020-05-03, release date: 2021-05-05, Last modification date: 2022-05-18)

• Primary citation: Long, H.,Zheng, W.,Liu, Y.,Sun, Y.,Zhao, K.,Liu, Z.,Xia, W.,Lv, S.,Liu, Z.,Li, D.,He, K.W.,Liu, C.; Wild-type alpha-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33972418; DOI: 10.1073/pnas.2012435118

Experimental method

ELECTRON MICROSCOPY (3.8 Å)