6EHA

Heme oxygenase 1 in complex with inhibitor

Summary for 6EHA

• Entry DOI: 10.2210/pdb6eha/pdb
• Descriptor: Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-(3-imidazol-1-ylpropyl)-5-(2-methylpropyl)-4-phenyl-imidazole, ... (4 entities in total)
• Functional Keywords: heme oxygenase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67570.93

Authors

Grudnik, P.,Mieczkowski, M. (deposition date: 2017-09-12, release date: 2018-10-10, Last modification date: 2019-10-23)

• Primary citation: Mucha, O.,Podkalicka, P.,Mikulski, M.,Barwacz, S.,Andrysiak, K.,Biela, A.,Mieczkowski, M.,Kachamakova-Trojanowska, N.,Ryszawy, D.,Bialas, A.,Szelazek, B.,Grudnik, P.,Majewska, E.,Michalik, K.,Jakubiec, K.,Bien, M.,Witkowska, N.,Gluza, K.,Ekonomiuk, D.,Sitarz, K.,Galezowski, M.,Brzozka, K.,Dubin, G.,Jozkowicz, A.,Dulak, J.,Loboda, A.; Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment.; Arch.Biochem.Biophys., 671:130-142, 2019; PubMed: 31276659; DOI: 10.1016/j.abb.2019.07.002

Experimental method

X-RAY DIFFRACTION (2 Å)