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6EHA

Heme oxygenase 1 in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001935biological_processendothelial cell proliferation
A0002246biological_processwound healing involved in inflammatory response
A0002686biological_processnegative regulation of leukocyte migration
A0004392molecular_functionheme oxygenase (decyclizing) activity
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006357biological_processregulation of transcription by RNA polymerase II
A0006788biological_processheme oxidation
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0014806biological_processsmooth muscle hyperplasia
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016239biological_processpositive regulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016491molecular_functionoxidoreductase activity
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0032722biological_processpositive regulation of chemokine production
A0034101biological_processerythrocyte homeostasis
A0034383biological_processlow-density lipoprotein particle clearance
A0034605biological_processcellular response to heat
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0042167biological_processheme catabolic process
A0042168biological_processheme metabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045765biological_processregulation of angiogenesis
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0071243biological_processcellular response to arsenic-containing substance
A0071276biological_processcellular response to cadmium ion
A0072719biological_processcellular response to cisplatin
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0110076biological_processnegative regulation of ferroptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1904019biological_processepithelial cell apoptotic process
A1904037biological_processpositive regulation of epithelial cell apoptotic process
B0001525biological_processangiogenesis
B0001935biological_processendothelial cell proliferation
B0002246biological_processwound healing involved in inflammatory response
B0002686biological_processnegative regulation of leukocyte migration
B0004392molecular_functionheme oxygenase (decyclizing) activity
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006357biological_processregulation of transcription by RNA polymerase II
B0006788biological_processheme oxidation
B0006879biological_processintracellular iron ion homeostasis
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0014806biological_processsmooth muscle hyperplasia
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016239biological_processpositive regulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016491molecular_functionoxidoreductase activity
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0032722biological_processpositive regulation of chemokine production
B0034101biological_processerythrocyte homeostasis
B0034383biological_processlow-density lipoprotein particle clearance
B0034605biological_processcellular response to heat
B0035094biological_processresponse to nicotine
B0035556biological_processintracellular signal transduction
B0042167biological_processheme catabolic process
B0042168biological_processheme metabolic process
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045765biological_processregulation of angiogenesis
B0045766biological_processpositive regulation of angiogenesis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0071243biological_processcellular response to arsenic-containing substance
B0071276biological_processcellular response to cadmium ion
B0072719biological_processcellular response to cisplatin
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0110076biological_processnegative regulation of ferroptosis
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B1904019biological_processepithelial cell apoptotic process
B1904037biological_processpositive regulation of epithelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue HEM A 301
ChainResidue
ALYS18
APHE207
AASN210
APHE214
AB5B302
AHOH401
AHOH428
AHOH453
AHIS25
AALA28
AMET34
AGLN38
ATYR134
ATHR135
AGLY139
AARG183

site_idAC2
Number of Residues9
Detailsbinding site for residue B5B A 302
ChainResidue
APHE37
AVAL50
AARG136
AGLY139
AGLY143
ALEU147
AASN210
APHE214
AHEM301

site_idAC3
Number of Residues15
Detailsbinding site for residue HEM B 301
ChainResidue
BLYS18
BHIS25
BGLU29
BGLN38
BTYR134
BTHR135
BGLY139
BARG183
BPHE207
BASN210
BPHE214
BB5B302
BHOH447
BHOH484
BHOH491

site_idAC4
Number of Residues11
Detailsbinding site for residue B5B B 302
ChainResidue
BMET34
BLEU54
BARG136
BGLY139
BASP140
BGLY143
BLEU147
BASN210
BLEU213
BPHE214
BHEM301

Functional Information from PROSITE/UniProt
site_idPS00593
Number of Residues11
DetailsHEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG
ChainResidueDetails
ALEU129-GLY139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues528
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:22419571
ChainResidueDetails
AMET1-ALA265
BMET1-ALA265

site_idSWS_FT_FI2
Number of Residues44
DetailsTRANSMEM: Helical; Anchor for type IV membrane protein => ECO:0000255
ChainResidueDetails
APRO266-MET288
BPRO266-MET288

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW
ChainResidueDetails
ALYS18
ATYR134
AARG183
BLYS18
BTYR134
BARG183

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW
ChainResidueDetails
AHIS25
BHIS25

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Important for catalytic activity => ECO:0000269|PubMed:11121422
ChainResidueDetails
AASP140
BASP140

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER229
BSER229

222624

PDB entries from 2024-07-17

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