7PW6
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body
Summary for 7PW6
Entry DOI | 10.2210/pdb7pw6/pdb |
EMDB information | 13676 |
Descriptor | Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1, INOSITOL HEXAKISPHOSPHATE, 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea (3 entities in total) |
Functional Keywords | complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 322128.08 |
Authors | Langer, L.M.,Conti, E. (deposition date: 2021-10-06, release date: 2021-12-01, Last modification date: 2024-07-17) |
Primary citation | Langer, L.M.,Bonneau, F.,Gat, Y.,Conti, E. Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10:-, 2021 Cited by PubMed: 34698635DOI: 10.7554/eLife.72353 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.05 Å) |
Structure validation
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