7PW6

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. StAvmsMvgYIIgLgDRHldN

Chain	Residue	Details
A	SER2320-ASN2340

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Repeat: {"description":"HEAT"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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