7PW6

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. StAvmsMvgYIIgLgDRHldN

Chain	Residue	Details
A	SER2320-ASN2340

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR3550

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER3556

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER3570

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR3573

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8BKX6

Chain	Residue	Details
A	THR3577

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