7PW6

Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1	polymer	2896	320902.0	1	UniProt (Q96Q15) Pfam (PF15785) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,SMG-1,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein
2	A	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)
3	A	1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea	non-polymer		566.1	1	Chemie (88C)

Sequence modifications

A: 766 - 1638 (UniProt: Q96Q15)

PDB	External Database	Details
Ser 1209	Ala 1209	conflict
Asn 1269	Asp 1269	conflict

A: 1639 - 1726 (PDB: 7PW6)
A: 1727 - 1978 (UniProt: Q96Q15)
A: 1979 - 2034 (PDB: 7PW6)
A: 2035 - 2056 (UniProt: Q96Q15)
A: 2057 - 2087 (PDB: 7PW6)
A: 2088 - 3661 (UniProt: Q96Q15)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.