7T3A

GATOR1-RAG-RAGULATOR - Inhibitory Complex

Summary for 7T3A

Entry DOI	10.2210/pdb7t3a/pdb
EMDB information	25652
Descriptor	GATOR complex protein DEPDC5, Ragulator complex protein LAMTOR5, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (11 entities in total)
Functional Keywords	complex, gtpase activating protein, nutrient sensing, metabolism, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	435600.48
Authors	Egri, S.B.,Shen, K. (deposition date: 2021-12-07, release date: 2022-04-06, Last modification date: 2022-06-01)
Primary citation	Egri, S.B.,Ouch, C.,Chou, H.T.,Yu, Z.,Song, K.,Xu, C.,Shen, K. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82:1836-, 2022 Cited by PubMed: 35338845 DOI: 10.1016/j.molcel.2022.03.002 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation